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Anxiolytic effects of chlordiazepoxide blocked by injection of GABAA and benzodiazepine receptor antagonists in the region of the anterior basolateral amygdala of rats.
Biol Psychiatry. 1995 Apr 01; 37(7):473-6.BP

Abstract

The amygdala is a structure that is often implicated in the regulation of anxiety responses. Many studies have shown that injection of benzodiazepines into the amygdala produces an anxiolytic effect. The present study was undertaken to determine whether the anxiolytic effect of administration of systemic benzodiazepine (chlordiazepoxide) might be blocked by local injection of a benzodiazepine receptor antagonist (flumazenil) or GABAA receptor antagonist (bicuculline methiodide; BMI) into the region of the anterior basolateral amygdala (BLA) of rats using an ethologically based test of anxiety, the social interaction test. Injection of flumazenil or BMI into the BLA of rats was found to reverse the anxiolytic effects of peripherally administered chlordiazepoxide. These results suggest a major role for the BLA in mediating the anxiolytic effects of benzodiazepines.

Authors+Show Affiliations

Indiana University School of Medicine, Department of Psychiatry, Indianapolis, IN, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7786962

Citation

Sanders, S K., and A Shekhar. "Anxiolytic Effects of Chlordiazepoxide Blocked By Injection of GABAA and Benzodiazepine Receptor Antagonists in the Region of the Anterior Basolateral Amygdala of Rats." Biological Psychiatry, vol. 37, no. 7, 1995, pp. 473-6.
Sanders SK, Shekhar A. Anxiolytic effects of chlordiazepoxide blocked by injection of GABAA and benzodiazepine receptor antagonists in the region of the anterior basolateral amygdala of rats. Biol Psychiatry. 1995;37(7):473-6.
Sanders, S. K., & Shekhar, A. (1995). Anxiolytic effects of chlordiazepoxide blocked by injection of GABAA and benzodiazepine receptor antagonists in the region of the anterior basolateral amygdala of rats. Biological Psychiatry, 37(7), 473-6.
Sanders SK, Shekhar A. Anxiolytic Effects of Chlordiazepoxide Blocked By Injection of GABAA and Benzodiazepine Receptor Antagonists in the Region of the Anterior Basolateral Amygdala of Rats. Biol Psychiatry. 1995 Apr 1;37(7):473-6. PubMed PMID: 7786962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic effects of chlordiazepoxide blocked by injection of GABAA and benzodiazepine receptor antagonists in the region of the anterior basolateral amygdala of rats. AU - Sanders,S K, AU - Shekhar,A, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 473 EP - 6 JF - Biological psychiatry JO - Biol Psychiatry VL - 37 IS - 7 N2 - The amygdala is a structure that is often implicated in the regulation of anxiety responses. Many studies have shown that injection of benzodiazepines into the amygdala produces an anxiolytic effect. The present study was undertaken to determine whether the anxiolytic effect of administration of systemic benzodiazepine (chlordiazepoxide) might be blocked by local injection of a benzodiazepine receptor antagonist (flumazenil) or GABAA receptor antagonist (bicuculline methiodide; BMI) into the region of the anterior basolateral amygdala (BLA) of rats using an ethologically based test of anxiety, the social interaction test. Injection of flumazenil or BMI into the BLA of rats was found to reverse the anxiolytic effects of peripherally administered chlordiazepoxide. These results suggest a major role for the BLA in mediating the anxiolytic effects of benzodiazepines. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/7786962/Anxiolytic_effects_of_chlordiazepoxide_blocked_by_injection_of_GABAA_and_benzodiazepine_receptor_antagonists_in_the_region_of_the_anterior_basolateral_amygdala_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-3223(94)00183-4 DB - PRIME DP - Unbound Medicine ER -