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[Decrease in common carotid artery intimal thickness after hypolipemic therapy].
Cas Lek Cesk. 1995 May 17; 134(10):306-9.CL

Abstract

BACKGROUND

In recent years evidence was provided that it is possible to assess sonographically the thickness of the intima of the common carotid artery, whereby an increase of the thickness of the intima is considered an early stage of atherosclerosis. In the submitted work the authors tried to assess whether it is possible to influence the thickness of the intima by therapy.

METHOD AND RESULTS

In 32 patients with familial hyperlipoproteinaemia sonographic control examinations of the common carotid artery were performed after 27 months of comprehensive treatment. In 21 subjects with familial hypercholesterolaemia the thickness of the intima decreased from 0.83 mm to 0.68 mm (p < 0.01), in 8 subjects with familial combined hyperlipoproteinaemia from 0.77 mm to 0.74 mm (a decline was recorded in half the subjects). In the whole group the greatest decrease was recorded in subjects treated with statins and a smaller decrease in those treated with fibrates.

CONCLUSIONS

The authors assume that the decrease of the thickness of the intima of the common carotid artery recorded in hyperlipoproteinaemic patients after hypolipidaemic treatment is a manifestation of regression of atherosclerosis.

Authors+Show Affiliations

III. interní klinika VFN a l. LF UK, Praha.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

cze

PubMed ID

7788649

Citation

Spácil, J, et al. "[Decrease in Common Carotid Artery Intimal Thickness After Hypolipemic Therapy]." Casopis Lekaru Ceskych, vol. 134, no. 10, 1995, pp. 306-9.
Spácil J, Ceska R, Sobra J, et al. [Decrease in common carotid artery intimal thickness after hypolipemic therapy]. Cas Lek Cesk. 1995;134(10):306-9.
Spácil, J., Ceska, R., Sobra, J., & Petrásek, J. (1995). [Decrease in common carotid artery intimal thickness after hypolipemic therapy]. Casopis Lekaru Ceskych, 134(10), 306-9.
Spácil J, et al. [Decrease in Common Carotid Artery Intimal Thickness After Hypolipemic Therapy]. Cas Lek Cesk. 1995 May 17;134(10):306-9. PubMed PMID: 7788649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Decrease in common carotid artery intimal thickness after hypolipemic therapy]. AU - Spácil,J, AU - Ceska,R, AU - Sobra,J, AU - Petrásek,J, PY - 1995/5/17/pubmed PY - 1995/5/17/medline PY - 1995/5/17/entrez SP - 306 EP - 9 JF - Casopis lekaru ceskych JO - Cas Lek Cesk VL - 134 IS - 10 N2 - BACKGROUND: In recent years evidence was provided that it is possible to assess sonographically the thickness of the intima of the common carotid artery, whereby an increase of the thickness of the intima is considered an early stage of atherosclerosis. In the submitted work the authors tried to assess whether it is possible to influence the thickness of the intima by therapy. METHOD AND RESULTS: In 32 patients with familial hyperlipoproteinaemia sonographic control examinations of the common carotid artery were performed after 27 months of comprehensive treatment. In 21 subjects with familial hypercholesterolaemia the thickness of the intima decreased from 0.83 mm to 0.68 mm (p < 0.01), in 8 subjects with familial combined hyperlipoproteinaemia from 0.77 mm to 0.74 mm (a decline was recorded in half the subjects). In the whole group the greatest decrease was recorded in subjects treated with statins and a smaller decrease in those treated with fibrates. CONCLUSIONS: The authors assume that the decrease of the thickness of the intima of the common carotid artery recorded in hyperlipoproteinaemic patients after hypolipidaemic treatment is a manifestation of regression of atherosclerosis. SN - 0008-7335 UR - https://www.unboundmedicine.com/medline/citation/7788649/[Decrease_in_common_carotid_artery_intimal_thickness_after_hypolipemic_therapy]_ DB - PRIME DP - Unbound Medicine ER -