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Gastric secretory response to different doses of carbachol and pentagastrin in man.
Scand J Gastroenterol. 1976; 11(4):421-5.SJ

Abstract

In 6 healthy students, the gastric secretion of acid, pepsin, and IF was measured during one hour at basal conditions, and during one hour of stimulation with 0.01 mug/kg/h and thereafter during one hour of stimulation with 0.1 mug/kg/h of pentagastrin. On separate days the same dose of pentagastrin was given in combination with 0.15 mug/kg/h or 1.5 mug/kg/h of carbachol, or stimulation was performed with each of the two doses of carbachol alone. A dose-dependent relationship was found between carbachol and the output of acid, pepsin, and IF. The responses to carbachol were independent of changes in plasma gastrin concentration. The acid- and IF-secretions stimulated by the largest dose of pentagastrin were significantly increased by the largest dose of carbachol, whereas the secretion of pepsin was not. Pentagastrin and carbachol seem to interact by competitive augmentation on the gastric secretion of acid and IF.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

779004

Citation

Vatn, M H., and J Myren. "Gastric Secretory Response to Different Doses of Carbachol and Pentagastrin in Man." Scandinavian Journal of Gastroenterology, vol. 11, no. 4, 1976, pp. 421-5.
Vatn MH, Myren J. Gastric secretory response to different doses of carbachol and pentagastrin in man. Scand J Gastroenterol. 1976;11(4):421-5.
Vatn, M. H., & Myren, J. (1976). Gastric secretory response to different doses of carbachol and pentagastrin in man. Scandinavian Journal of Gastroenterology, 11(4), 421-5.
Vatn MH, Myren J. Gastric Secretory Response to Different Doses of Carbachol and Pentagastrin in Man. Scand J Gastroenterol. 1976;11(4):421-5. PubMed PMID: 779004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric secretory response to different doses of carbachol and pentagastrin in man. AU - Vatn,M H, AU - Myren,J, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 421 EP - 5 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 11 IS - 4 N2 - In 6 healthy students, the gastric secretion of acid, pepsin, and IF was measured during one hour at basal conditions, and during one hour of stimulation with 0.01 mug/kg/h and thereafter during one hour of stimulation with 0.1 mug/kg/h of pentagastrin. On separate days the same dose of pentagastrin was given in combination with 0.15 mug/kg/h or 1.5 mug/kg/h of carbachol, or stimulation was performed with each of the two doses of carbachol alone. A dose-dependent relationship was found between carbachol and the output of acid, pepsin, and IF. The responses to carbachol were independent of changes in plasma gastrin concentration. The acid- and IF-secretions stimulated by the largest dose of pentagastrin were significantly increased by the largest dose of carbachol, whereas the secretion of pepsin was not. Pentagastrin and carbachol seem to interact by competitive augmentation on the gastric secretion of acid and IF. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/779004/Gastric_secretory_response_to_different_doses_of_carbachol_and_pentagastrin_in_man_ DB - PRIME DP - Unbound Medicine ER -