Tags

Type your tag names separated by a space and hit enter

Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra.
J Pharmacol Exp Ther. 1995 Jun; 273(3):1063-70.JP

Abstract

The effects of the amphetamine analog, 3,4-methylenedioxymethamphetamine (MDMA) were compared to the effects of d-amphetamine on the in vivo release of dopamine and gamma-aminobutyric acid (GABA) in the striatum and substantia nigra. The brain region-dependent role of the 5-HT2 receptors in the striatum and substantia nigra in regulating MDMA-induced dopamine and GABA release also was studied. Changes in the extracellular concentration of dopamine, 5-HT and GABA were measured simultaneously in the awake rat by in vivo microdialysis. The increase in striatal dopamine produced by systemic administration of MDMA was attenuated by infusion of TTX into the striatum. Infusion of the 5-HT2A/2C antagonist ritanserin into the striatum or the ipsilateral substantia nigra also significantly attenuated MDMA-induced dopamine release in the striatum. At the doses used in this study, MDMA but not d-amphetamine increased the extracellular concentrations of 5-HT and decreased GABA efflux in the substantia nigra. The ability of MDMA to decrease nigral GABA efflux also was blocked by the local infusion of ritanserin into either the substantia nigra or the striatum. Overall, these data provide evidence that MDMA increases dopamine release partly through an impulse-mediated mechanism. Furthermore, this increase in striatal dopamine efflux produced by MDMA is regulated, in part, by 5-HT2A/2C receptors in the striatum and the substantia nigra and ultimately by GABAergic input into the substantia nigra.

Authors+Show Affiliations

Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7791076

Citation

Yamamoto, B K., et al. "Modulation of Methylenedioxymethamphetamine-induced Striatal Dopamine Release By the Interaction Between Serotonin and Gamma-aminobutyric Acid in the Substantia Nigra." The Journal of Pharmacology and Experimental Therapeutics, vol. 273, no. 3, 1995, pp. 1063-70.
Yamamoto BK, Nash JF, Gudelsky GA. Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra. J Pharmacol Exp Ther. 1995;273(3):1063-70.
Yamamoto, B. K., Nash, J. F., & Gudelsky, G. A. (1995). Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra. The Journal of Pharmacology and Experimental Therapeutics, 273(3), 1063-70.
Yamamoto BK, Nash JF, Gudelsky GA. Modulation of Methylenedioxymethamphetamine-induced Striatal Dopamine Release By the Interaction Between Serotonin and Gamma-aminobutyric Acid in the Substantia Nigra. J Pharmacol Exp Ther. 1995;273(3):1063-70. PubMed PMID: 7791076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra. AU - Yamamoto,B K, AU - Nash,J F, AU - Gudelsky,G A, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 1063 EP - 70 JF - The Journal of pharmacology and experimental therapeutics JO - J. Pharmacol. Exp. Ther. VL - 273 IS - 3 N2 - The effects of the amphetamine analog, 3,4-methylenedioxymethamphetamine (MDMA) were compared to the effects of d-amphetamine on the in vivo release of dopamine and gamma-aminobutyric acid (GABA) in the striatum and substantia nigra. The brain region-dependent role of the 5-HT2 receptors in the striatum and substantia nigra in regulating MDMA-induced dopamine and GABA release also was studied. Changes in the extracellular concentration of dopamine, 5-HT and GABA were measured simultaneously in the awake rat by in vivo microdialysis. The increase in striatal dopamine produced by systemic administration of MDMA was attenuated by infusion of TTX into the striatum. Infusion of the 5-HT2A/2C antagonist ritanserin into the striatum or the ipsilateral substantia nigra also significantly attenuated MDMA-induced dopamine release in the striatum. At the doses used in this study, MDMA but not d-amphetamine increased the extracellular concentrations of 5-HT and decreased GABA efflux in the substantia nigra. The ability of MDMA to decrease nigral GABA efflux also was blocked by the local infusion of ritanserin into either the substantia nigra or the striatum. Overall, these data provide evidence that MDMA increases dopamine release partly through an impulse-mediated mechanism. Furthermore, this increase in striatal dopamine efflux produced by MDMA is regulated, in part, by 5-HT2A/2C receptors in the striatum and the substantia nigra and ultimately by GABAergic input into the substantia nigra. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/7791076/Modulation_of_methylenedioxymethamphetamine_induced_striatal_dopamine_release_by_the_interaction_between_serotonin_and_gamma_aminobutyric_acid_in_the_substantia_nigra_ L2 - http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7791076 DB - PRIME DP - Unbound Medicine ER -