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HIV-1 prevalence and risk factors among sexually transmitted disease clinic attenders in Trinidad.
AIDS. 1995 Apr; 9(4):389-94.AIDS

Abstract

OBJECTIVES

To study trends in prevalence and to ascertain risk factors for HIV-1 among sexually transmitted disease (STD) clinic attenders in Trinidad.

DESIGN AND METHODS

Serial cross-sectional studies were conducted in 1987-1988 and 1990-1991 at a centralized STD clinic in Port of Spain. A case-control study was carried out to examine in greater detail the demographic and behavioral risk factors for HIV-1 among self-declared heterosexuals in this population.

RESULTS

HIV-1 prevalence increased from 3.0% [95% confidence interval (CI), 2.3-3.9] in 1987-1988 to 13.6% (95% CI, 11.8-15.6) in 1990-1991. Age > or = 40 years [odds ratio (OR), 2.0; 95% CI, 1.4-2.8], urban residence (OR, 2.2; 95% CI, 1.6-3.0), and human T-lymphotropic virus-I seropositivity (OR, 3.1; 95% CI, 1.6-6.0) were significant risk factors for HIV-1 in 1990-1991. In the case-control analysis, significant independent risk factors for men included current genital ulcer disease (OR, 5.2; 95% CI, 2.2-12.5), current genital warts (OR, 3.9; 95% CI, 1.2-12.0), having ever had syphilis (OR, 3.2; 95% CI 1.6-6.1), and use of crack cocaine in the preceding 6 months (OR, 6.2; 95% CI, 2.7-14.2). Corresponding risk factors for women were commercial sex work (OR, 5.7; 95% CI, 1.3-25.7), initiation of sexual activity before age 14 years (OR, 4.8; 95% CI, 1.5-16.0), and past non-gonococcal cervicitis (OR, 4.1; 95% CI, 1.3-13.1).

CONCLUSIONS

HIV-1 in this setting is primarily heterosexually transmitted in a milieu of unprotected sexual activity fuelled by a crack cocaine epidemic. Targeted interventions to prevent, detect and treat STD and crack cocaine addiction, as well as disrupt their adverse synergism, may substantially reduce HIV-1 transmission in this population.

Authors+Show Affiliations

Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7794544

Citation

Cleghorn, F R., et al. "HIV-1 Prevalence and Risk Factors Among Sexually Transmitted Disease Clinic Attenders in Trinidad." AIDS (London, England), vol. 9, no. 4, 1995, pp. 389-94.
Cleghorn FR, Jack N, Murphy JR, et al. HIV-1 prevalence and risk factors among sexually transmitted disease clinic attenders in Trinidad. AIDS. 1995;9(4):389-94.
Cleghorn, F. R., Jack, N., Murphy, J. R., Edwards, J., Mahabir, B., Paul, R., White, F., Bartholomew, C., & Blattner, W. A. (1995). HIV-1 prevalence and risk factors among sexually transmitted disease clinic attenders in Trinidad. AIDS (London, England), 9(4), 389-94.
Cleghorn FR, et al. HIV-1 Prevalence and Risk Factors Among Sexually Transmitted Disease Clinic Attenders in Trinidad. AIDS. 1995;9(4):389-94. PubMed PMID: 7794544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HIV-1 prevalence and risk factors among sexually transmitted disease clinic attenders in Trinidad. AU - Cleghorn,F R, AU - Jack,N, AU - Murphy,J R, AU - Edwards,J, AU - Mahabir,B, AU - Paul,R, AU - White,F, AU - Bartholomew,C, AU - Blattner,W A, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez KW - Americas KW - Behavior KW - Biology KW - Caribbean KW - Case Control Studies KW - Cross Sectional Analysis KW - Developing Countries KW - Diseases KW - Drug Addiction KW - Heterosexuals KW - Hiv Infections--determinants KW - Infections KW - Measurement KW - North America KW - Prevalence KW - Prostitutes KW - Reproductive Tract Infections KW - Research Report KW - Risk Factors KW - Sex Behavior KW - Sexually Transmitted Diseases KW - Social Problems KW - Studies KW - Substance Addiction KW - Trinidad And Tobago KW - Viral Diseases SP - 389 EP - 94 JF - AIDS (London, England) JO - AIDS VL - 9 IS - 4 N2 - OBJECTIVES: To study trends in prevalence and to ascertain risk factors for HIV-1 among sexually transmitted disease (STD) clinic attenders in Trinidad. DESIGN AND METHODS: Serial cross-sectional studies were conducted in 1987-1988 and 1990-1991 at a centralized STD clinic in Port of Spain. A case-control study was carried out to examine in greater detail the demographic and behavioral risk factors for HIV-1 among self-declared heterosexuals in this population. RESULTS: HIV-1 prevalence increased from 3.0% [95% confidence interval (CI), 2.3-3.9] in 1987-1988 to 13.6% (95% CI, 11.8-15.6) in 1990-1991. Age > or = 40 years [odds ratio (OR), 2.0; 95% CI, 1.4-2.8], urban residence (OR, 2.2; 95% CI, 1.6-3.0), and human T-lymphotropic virus-I seropositivity (OR, 3.1; 95% CI, 1.6-6.0) were significant risk factors for HIV-1 in 1990-1991. In the case-control analysis, significant independent risk factors for men included current genital ulcer disease (OR, 5.2; 95% CI, 2.2-12.5), current genital warts (OR, 3.9; 95% CI, 1.2-12.0), having ever had syphilis (OR, 3.2; 95% CI 1.6-6.1), and use of crack cocaine in the preceding 6 months (OR, 6.2; 95% CI, 2.7-14.2). Corresponding risk factors for women were commercial sex work (OR, 5.7; 95% CI, 1.3-25.7), initiation of sexual activity before age 14 years (OR, 4.8; 95% CI, 1.5-16.0), and past non-gonococcal cervicitis (OR, 4.1; 95% CI, 1.3-13.1). CONCLUSIONS: HIV-1 in this setting is primarily heterosexually transmitted in a milieu of unprotected sexual activity fuelled by a crack cocaine epidemic. Targeted interventions to prevent, detect and treat STD and crack cocaine addiction, as well as disrupt their adverse synergism, may substantially reduce HIV-1 transmission in this population. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/7794544/HIV_1_prevalence_and_risk_factors_among_sexually_transmitted_disease_clinic_attenders_in_Trinidad_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7794544.ui DB - PRIME DP - Unbound Medicine ER -