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A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q.
Nat Genet. 1995 Apr; 9(4):418-23.NGen

Abstract

Maturity-onset diabetes of the young (MODY) is a subtype of non-insulin dependent diabetes mellitus, with early age of onset. MODY is genetically heterogeneous, associated with glucokinase mutations and a locus on chromosome 20q; in about 50% of cases, its genetic background is unknown. We have studied 12 families in which MODY is unlinked to either glucokinase or chromosome 20q markers, and find significant evidence for linkage with microsatellite markers on chromosome 12q, most likely within a 7 centimogran interval bracketed by D12S86 and D12S342. The disease was estimated to be linked to this chromosome region in approximately 50% of families in a heterogeneity analysis. These MODY patients exhibit major hyperglycaemia with a severe insulin secretory defect, suggesting that the causal gene is implicated in pancreatic beta-cell function.

Authors+Show Affiliations

CNRS EP10, Institut Pasteur de Lille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7795649

Citation

Vaxillaire, M, et al. "A Gene for Maturity Onset Diabetes of the Young (MODY) Maps to Chromosome 12q." Nature Genetics, vol. 9, no. 4, 1995, pp. 418-23.
Vaxillaire M, Boccio V, Philippi A, et al. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat Genet. 1995;9(4):418-23.
Vaxillaire, M., Boccio, V., Philippi, A., Vigouroux, C., Terwilliger, J., Passa, P., Beckmann, J. S., Velho, G., Lathrop, G. M., & Froguel, P. (1995). A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nature Genetics, 9(4), 418-23.
Vaxillaire M, et al. A Gene for Maturity Onset Diabetes of the Young (MODY) Maps to Chromosome 12q. Nat Genet. 1995;9(4):418-23. PubMed PMID: 7795649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. AU - Vaxillaire,M, AU - Boccio,V, AU - Philippi,A, AU - Vigouroux,C, AU - Terwilliger,J, AU - Passa,P, AU - Beckmann,J S, AU - Velho,G, AU - Lathrop,G M, AU - Froguel,P, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 418 EP - 23 JF - Nature genetics JO - Nat. Genet. VL - 9 IS - 4 N2 - Maturity-onset diabetes of the young (MODY) is a subtype of non-insulin dependent diabetes mellitus, with early age of onset. MODY is genetically heterogeneous, associated with glucokinase mutations and a locus on chromosome 20q; in about 50% of cases, its genetic background is unknown. We have studied 12 families in which MODY is unlinked to either glucokinase or chromosome 20q markers, and find significant evidence for linkage with microsatellite markers on chromosome 12q, most likely within a 7 centimogran interval bracketed by D12S86 and D12S342. The disease was estimated to be linked to this chromosome region in approximately 50% of families in a heterogeneity analysis. These MODY patients exhibit major hyperglycaemia with a severe insulin secretory defect, suggesting that the causal gene is implicated in pancreatic beta-cell function. SN - 1061-4036 UR - https://www.unboundmedicine.com/medline/citation/7795649/A_gene_for_maturity_onset_diabetes_of_the_young__MODY__maps_to_chromosome_12q_ L2 - http://dx.doi.org/10.1038/ng0495-418 DB - PRIME DP - Unbound Medicine ER -