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Multicenter trial of two monophasic oral contraceptives containing 30 mcg ethinylestradiol and either desogestrel or gestodene in Thai women.
Contraception. 1995 Apr; 51(4):225-9.C

Abstract

The efficacy and acceptability of two third generation oral contraceptives in Thai women were evaluated in a prospective, open, group-comparative, randomized, multicenter trial of women asking for contraception. In six Family Planning Centers and Outpatient Gynaecological Clinics in urban areas in Thailand, 783 healthy women who were at risk for pregnancy and did not have contraindications to oral contraceptive use were randomly allocated to one of the two study groups. An oral contraceptive containing 30 mcg ethinylestradiol and 150 mcg desogestrel was given to 394 women and an oral contraceptive with the same amount of ethinylestradiol and 75 mcg gestodene to 389 women during 6 cycles. Criteria of cycle control, side effects and the presence and severity of acne vulgaris were assessed and blood pressure and body weight measured at pretreatment and after cycles 1, 3 and 6. Furthermore, the efficacy was evaluated after the last cycle. No pregnancies occurred with either of the contraceptives. The incidences of irregular bleeding and minor side effects in both groups were very low and decreased after an initial increase in the first cycle. Acne improved in both groups. Blood pressure and body weight remained unchanged. The two oral contraceptives were found to be effective and acceptable in Thai women. Compared to Caucasian women, the incidences of irregular bleeding and side effects were apparently lower in these Asian women. Furthermore, the effects of both oral contraceptives were comparable.

Authors+Show Affiliations

Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7796587

Citation

Koetsawang, S, et al. "Multicenter Trial of Two Monophasic Oral Contraceptives Containing 30 Mcg Ethinylestradiol and Either Desogestrel or Gestodene in Thai Women." Contraception, vol. 51, no. 4, 1995, pp. 225-9.
Koetsawang S, Charoenvisal C, Banharnsupawat L, et al. Multicenter trial of two monophasic oral contraceptives containing 30 mcg ethinylestradiol and either desogestrel or gestodene in Thai women. Contraception. 1995;51(4):225-9.
Koetsawang, S., Charoenvisal, C., Banharnsupawat, L., Singhakovin, S., Kaewsuk, O., & Punnahitanont, S. (1995). Multicenter trial of two monophasic oral contraceptives containing 30 mcg ethinylestradiol and either desogestrel or gestodene in Thai women. Contraception, 51(4), 225-9.
Koetsawang S, et al. Multicenter Trial of Two Monophasic Oral Contraceptives Containing 30 Mcg Ethinylestradiol and Either Desogestrel or Gestodene in Thai Women. Contraception. 1995;51(4):225-9. PubMed PMID: 7796587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multicenter trial of two monophasic oral contraceptives containing 30 mcg ethinylestradiol and either desogestrel or gestodene in Thai women. AU - Koetsawang,S, AU - Charoenvisal,C, AU - Banharnsupawat,L, AU - Singhakovin,S, AU - Kaewsuk,O, AU - Punnahitanont,S, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez KW - Asia KW - Asians--women KW - Clinical Research KW - Clinical Trials KW - Comparative Studies KW - Contraception KW - Contraception Continuation KW - Contraceptive Agents, Estrogen--side effects KW - Contraceptive Agents, Female--side effects KW - Contraceptive Agents, Progestin--side effects KW - Contraceptive Agents--side effects KW - Contraceptive Effectiveness KW - Contraceptive Methods KW - Contraceptive Usage KW - Cultural Background KW - Demographic Factors KW - Desogestrel--side effects KW - Developing Countries KW - Diseases KW - Ethinyl Estradiol--side effects KW - Ethnic Groups KW - Family Planning KW - Gestodene--side effects KW - Menstruation Disorders KW - Method Acceptability KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Population KW - Population Characteristics KW - Research Report KW - Southeastern Asia KW - Studies KW - Thailand KW - Whites--women SP - 225 EP - 9 JF - Contraception JO - Contraception VL - 51 IS - 4 N2 - The efficacy and acceptability of two third generation oral contraceptives in Thai women were evaluated in a prospective, open, group-comparative, randomized, multicenter trial of women asking for contraception. In six Family Planning Centers and Outpatient Gynaecological Clinics in urban areas in Thailand, 783 healthy women who were at risk for pregnancy and did not have contraindications to oral contraceptive use were randomly allocated to one of the two study groups. An oral contraceptive containing 30 mcg ethinylestradiol and 150 mcg desogestrel was given to 394 women and an oral contraceptive with the same amount of ethinylestradiol and 75 mcg gestodene to 389 women during 6 cycles. Criteria of cycle control, side effects and the presence and severity of acne vulgaris were assessed and blood pressure and body weight measured at pretreatment and after cycles 1, 3 and 6. Furthermore, the efficacy was evaluated after the last cycle. No pregnancies occurred with either of the contraceptives. The incidences of irregular bleeding and minor side effects in both groups were very low and decreased after an initial increase in the first cycle. Acne improved in both groups. Blood pressure and body weight remained unchanged. The two oral contraceptives were found to be effective and acceptable in Thai women. Compared to Caucasian women, the incidences of irregular bleeding and side effects were apparently lower in these Asian women. Furthermore, the effects of both oral contraceptives were comparable. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/7796587/Multicenter_trial_of_two_monophasic_oral_contraceptives_containing_30_mcg_ethinylestradiol_and_either_desogestrel_or_gestodene_in_Thai_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/001078249500037B DB - PRIME DP - Unbound Medicine ER -