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Bone mass and metabolism in patients with celiac disease.
Gastroenterology 1995; 109(1):122-8G

Abstract

BACKGROUND & AIMS

Several aspects of the pathogenesis of osteopenia in celiac disease are still unclear. Therefore, bone mass and metabolism were evaluated in adults with celiac disease in a cross-sectional study.

METHODS

Bone mineral density (BMD), assessed by total body dual-photon absorptiometry, and serum indices of bone metabolism and remodeling were evaluated in 17 patients with untreated celiac disease, 14 with celiac disease on a gluten-free diet, and 24 healthy volunteers.

RESULTS

BMD, expressed as a z score, was significantly lower in patients with untreated celiac disease than in patients with treated celiac disease and volunteers and lower in patients with treated celiac disease than in volunteers. Similar changes were observed in serum calcium level, whereas intact parathyroid hormone level was significantly higher in untreated than in treated patients with celiac disease and volunteers, and no difference was found between the latter two groups. 25-Vitamin D level was significantly lower and 1,25-vitamin D level significantly higher in untreated celiac disease than in treated celiac disease and volunteers. Indices of bone remodeling were significantly higher in untreated than in treated patients and volunteers and significantly and positively correlated with iPTH in untreated patients with celiac disease.

CONCLUSIONS

BMD is almost invariably low in patients with untreated celiac disease. Results in treated patients suggest that gluten-free diet improves but does not normalize BMD. Untreated celiac disease is characterized by high levels of 1,25-vitamin D and by increased bone turnover, caused by the increase in intact parathyroid hormone level.

Authors+Show Affiliations

Department of Internal Medicine, University of L'Aquila, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7797010

Citation

Corazza, G R., et al. "Bone Mass and Metabolism in Patients With Celiac Disease." Gastroenterology, vol. 109, no. 1, 1995, pp. 122-8.
Corazza GR, Di Sario A, Cecchetti L, et al. Bone mass and metabolism in patients with celiac disease. Gastroenterology. 1995;109(1):122-8.
Corazza, G. R., Di Sario, A., Cecchetti, L., Tarozzi, C., Corrao, G., Bernardi, M., & Gasbarrini, G. (1995). Bone mass and metabolism in patients with celiac disease. Gastroenterology, 109(1), pp. 122-8.
Corazza GR, et al. Bone Mass and Metabolism in Patients With Celiac Disease. Gastroenterology. 1995;109(1):122-8. PubMed PMID: 7797010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mass and metabolism in patients with celiac disease. AU - Corazza,G R, AU - Di Sario,A, AU - Cecchetti,L, AU - Tarozzi,C, AU - Corrao,G, AU - Bernardi,M, AU - Gasbarrini,G, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 122 EP - 8 JF - Gastroenterology JO - Gastroenterology VL - 109 IS - 1 N2 - BACKGROUND & AIMS: Several aspects of the pathogenesis of osteopenia in celiac disease are still unclear. Therefore, bone mass and metabolism were evaluated in adults with celiac disease in a cross-sectional study. METHODS: Bone mineral density (BMD), assessed by total body dual-photon absorptiometry, and serum indices of bone metabolism and remodeling were evaluated in 17 patients with untreated celiac disease, 14 with celiac disease on a gluten-free diet, and 24 healthy volunteers. RESULTS: BMD, expressed as a z score, was significantly lower in patients with untreated celiac disease than in patients with treated celiac disease and volunteers and lower in patients with treated celiac disease than in volunteers. Similar changes were observed in serum calcium level, whereas intact parathyroid hormone level was significantly higher in untreated than in treated patients with celiac disease and volunteers, and no difference was found between the latter two groups. 25-Vitamin D level was significantly lower and 1,25-vitamin D level significantly higher in untreated celiac disease than in treated celiac disease and volunteers. Indices of bone remodeling were significantly higher in untreated than in treated patients and volunteers and significantly and positively correlated with iPTH in untreated patients with celiac disease. CONCLUSIONS: BMD is almost invariably low in patients with untreated celiac disease. Results in treated patients suggest that gluten-free diet improves but does not normalize BMD. Untreated celiac disease is characterized by high levels of 1,25-vitamin D and by increased bone turnover, caused by the increase in intact parathyroid hormone level. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/7797010/Bone_mass_and_metabolism_in_patients_with_celiac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0016-5085(95)90276-7 DB - PRIME DP - Unbound Medicine ER -