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Epidemiology of nasopharyngeal colonization with nontypeable Haemophilus influenzae in the first 2 years of life.
J Infect Dis. 1995 Jul; 172(1):132-5.JI

Abstract

Two hundred children were followed from birth through 2 years of age with nasopharyngeal cultures to determine the normal colonization pattern of nontypeable Haemophilus influenzae. Forty-four percent of the children were colonized on one or more occasions; the acquisition rate was greatest in the first year. Monthly prevalence rates were 11%. Colonization with the initial strain persisted 1-5 months (median, 2). Children carried 1 predominant strain at a time but became colonized with up to 7 different strains (mean, 2.2). Children colonized with a single strain for < or = 2 months produced a greater nasopharyngeal secretory IgA to nontypeable H. influenzae response than did children colonized with different strains (log 2.35 +/- 0.68 vs. 1.89 +/- 0.25 U of P6 secretory IgA/ng/mL of total secretory IgA, P < .01). The duration of colonization with a strain and acquisition of a new strain may be affected in part by the local production of specific secretory IgA.

Authors+Show Affiliations

Division of Infectious Diseases, State University of New York at Buffalo, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7797903

Citation

Faden, H, et al. "Epidemiology of Nasopharyngeal Colonization With Nontypeable Haemophilus Influenzae in the First 2 Years of Life." The Journal of Infectious Diseases, vol. 172, no. 1, 1995, pp. 132-5.
Faden H, Duffy L, Williams A, et al. Epidemiology of nasopharyngeal colonization with nontypeable Haemophilus influenzae in the first 2 years of life. J Infect Dis. 1995;172(1):132-5.
Faden, H., Duffy, L., Williams, A., Krystofik, D. A., & Wolf, J. (1995). Epidemiology of nasopharyngeal colonization with nontypeable Haemophilus influenzae in the first 2 years of life. The Journal of Infectious Diseases, 172(1), 132-5.
Faden H, et al. Epidemiology of Nasopharyngeal Colonization With Nontypeable Haemophilus Influenzae in the First 2 Years of Life. J Infect Dis. 1995;172(1):132-5. PubMed PMID: 7797903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of nasopharyngeal colonization with nontypeable Haemophilus influenzae in the first 2 years of life. AU - Faden,H, AU - Duffy,L, AU - Williams,A, AU - Krystofik,D A, AU - Wolf,J, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 132 EP - 5 JF - The Journal of infectious diseases JO - J Infect Dis VL - 172 IS - 1 N2 - Two hundred children were followed from birth through 2 years of age with nasopharyngeal cultures to determine the normal colonization pattern of nontypeable Haemophilus influenzae. Forty-four percent of the children were colonized on one or more occasions; the acquisition rate was greatest in the first year. Monthly prevalence rates were 11%. Colonization with the initial strain persisted 1-5 months (median, 2). Children carried 1 predominant strain at a time but became colonized with up to 7 different strains (mean, 2.2). Children colonized with a single strain for < or = 2 months produced a greater nasopharyngeal secretory IgA to nontypeable H. influenzae response than did children colonized with different strains (log 2.35 +/- 0.68 vs. 1.89 +/- 0.25 U of P6 secretory IgA/ng/mL of total secretory IgA, P < .01). The duration of colonization with a strain and acquisition of a new strain may be affected in part by the local production of specific secretory IgA. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/7797903/Epidemiology_of_nasopharyngeal_colonization_with_nontypeable_Haemophilus_influenzae_in_the_first_2_years_of_life_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/172.1.132 DB - PRIME DP - Unbound Medicine ER -