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The effect of cisapride on delayed colonic transit time in patients with idiopathic Parkinson's disease.
Wien Klin Wochenschr. 1994; 106(21):673-6.WK

Abstract

Disorders of autonomic regulation are common in patients with Parkinson's disease (PD). Patients most frequently complain of dysphagia and therapy resistant constipation, as far as the gastrointestinal tract is concerned. These symptoms have to be attributed to a neuronal degeneration. In a pilot study we therefore investigated the effect of stimulation of the myenteric plexus by cisapride. 11 women and 13 men were examined, the average age was 67.3 years, the Webster rating 17 points. In 2 out of 24 patients, colonic transit was prolonged up to the limit, both with and without therapy. The other 22 patients showed an acceleration in transit on response to cisapride. On average the colonic transit of 130 hours was reduced to 79 hours. This objective improvement was associated with a subjective improvement. Central side effects or a worsening of Parkinsonian symptoms were not found. We conclude that cisapride is effective in the treatment of constipation in idiopathic PD.

Authors+Show Affiliations

Neurologische Klinik, Universität des Saarlandes, Homburg/Saar, Federal Republic of Germany.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

7810153

Citation

Jost, W H., and K Schimrigk. "The Effect of Cisapride On Delayed Colonic Transit Time in Patients With Idiopathic Parkinson's Disease." Wiener Klinische Wochenschrift, vol. 106, no. 21, 1994, pp. 673-6.
Jost WH, Schimrigk K. The effect of cisapride on delayed colonic transit time in patients with idiopathic Parkinson's disease. Wien Klin Wochenschr. 1994;106(21):673-6.
Jost, W. H., & Schimrigk, K. (1994). The effect of cisapride on delayed colonic transit time in patients with idiopathic Parkinson's disease. Wiener Klinische Wochenschrift, 106(21), 673-6.
Jost WH, Schimrigk K. The Effect of Cisapride On Delayed Colonic Transit Time in Patients With Idiopathic Parkinson's Disease. Wien Klin Wochenschr. 1994;106(21):673-6. PubMed PMID: 7810153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of cisapride on delayed colonic transit time in patients with idiopathic Parkinson's disease. AU - Jost,W H, AU - Schimrigk,K, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 673 EP - 6 JF - Wiener klinische Wochenschrift JO - Wien. Klin. Wochenschr. VL - 106 IS - 21 N2 - Disorders of autonomic regulation are common in patients with Parkinson's disease (PD). Patients most frequently complain of dysphagia and therapy resistant constipation, as far as the gastrointestinal tract is concerned. These symptoms have to be attributed to a neuronal degeneration. In a pilot study we therefore investigated the effect of stimulation of the myenteric plexus by cisapride. 11 women and 13 men were examined, the average age was 67.3 years, the Webster rating 17 points. In 2 out of 24 patients, colonic transit was prolonged up to the limit, both with and without therapy. The other 22 patients showed an acceleration in transit on response to cisapride. On average the colonic transit of 130 hours was reduced to 79 hours. This objective improvement was associated with a subjective improvement. Central side effects or a worsening of Parkinsonian symptoms were not found. We conclude that cisapride is effective in the treatment of constipation in idiopathic PD. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/7810153/The_effect_of_cisapride_on_delayed_colonic_transit_time_in_patients_with_idiopathic_Parkinson's_disease_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -