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Glutamine-enriched enteral diet increases splanchnic blood flow in the rat.
Am J Physiol 1994; 267(6 Pt 1):G1035-40AJ

Abstract

The hemodynamic consequences of glutamine (Gln)-enriched nutrition have not been investigated. This study investigates the effects of a Gln-enriched enteral diet on organ blood flows and systemic hemodynamics. Male Fischer 344 rats (n = 24) were randomized to a group that received a 12.5% (wt/wt) Gln-enriched enteral diet or an isonitrogenous isocaloric control diet for 14 days. Blood flow measurements were performed at day 16 using 46Sc-labeled microspheres. In the Gln-enriched group, higher organ blood flows were measured in the stomach (51%), the pancreas (35%), small intestine (32%), and colon (55%), compared with controls. No differences were found in systemic hemodynamic parameters between the control and Gln-supplemented groups. A possible role for nitric oxide in this splanchnic vasodilation was investigated. Daily urinary nitrate excretion was measured during the study but showed no significant differences between the control and Gln-fed animals. No differences were found in plasma levels of the vasodilating hormone glucagon between the groups. These results show that a Gln-enriched enteral diet increased splanchnic blood flow, which was not mediated by pancreatic glucagon or increased nitric oxide production as determined by urinary nitrate excretion.

Authors+Show Affiliations

Department of Surgery and Clinical Chemistry, Free University Hospital, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7810650

Citation

Houdijk, A P., et al. "Glutamine-enriched Enteral Diet Increases Splanchnic Blood Flow in the Rat." The American Journal of Physiology, vol. 267, no. 6 Pt 1, 1994, pp. G1035-40.
Houdijk AP, Van Leeuwen PA, Boermeester MA, et al. Glutamine-enriched enteral diet increases splanchnic blood flow in the rat. Am J Physiol. 1994;267(6 Pt 1):G1035-40.
Houdijk, A. P., Van Leeuwen, P. A., Boermeester, M. A., Van Lambalgen, T., Teerlink, T., Flinkerbusch, E. L., ... Wesdorp, R. I. (1994). Glutamine-enriched enteral diet increases splanchnic blood flow in the rat. The American Journal of Physiology, 267(6 Pt 1), pp. G1035-40.
Houdijk AP, et al. Glutamine-enriched Enteral Diet Increases Splanchnic Blood Flow in the Rat. Am J Physiol. 1994;267(6 Pt 1):G1035-40. PubMed PMID: 7810650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutamine-enriched enteral diet increases splanchnic blood flow in the rat. AU - Houdijk,A P, AU - Van Leeuwen,P A, AU - Boermeester,M A, AU - Van Lambalgen,T, AU - Teerlink,T, AU - Flinkerbusch,E L, AU - Sauerwein,H P, AU - Wesdorp,R I, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - G1035 EP - 40 JF - The American journal of physiology JO - Am. J. Physiol. VL - 267 IS - 6 Pt 1 N2 - The hemodynamic consequences of glutamine (Gln)-enriched nutrition have not been investigated. This study investigates the effects of a Gln-enriched enteral diet on organ blood flows and systemic hemodynamics. Male Fischer 344 rats (n = 24) were randomized to a group that received a 12.5% (wt/wt) Gln-enriched enteral diet or an isonitrogenous isocaloric control diet for 14 days. Blood flow measurements were performed at day 16 using 46Sc-labeled microspheres. In the Gln-enriched group, higher organ blood flows were measured in the stomach (51%), the pancreas (35%), small intestine (32%), and colon (55%), compared with controls. No differences were found in systemic hemodynamic parameters between the control and Gln-supplemented groups. A possible role for nitric oxide in this splanchnic vasodilation was investigated. Daily urinary nitrate excretion was measured during the study but showed no significant differences between the control and Gln-fed animals. No differences were found in plasma levels of the vasodilating hormone glucagon between the groups. These results show that a Gln-enriched enteral diet increased splanchnic blood flow, which was not mediated by pancreatic glucagon or increased nitric oxide production as determined by urinary nitrate excretion. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/7810650/Glutamine_enriched_enteral_diet_increases_splanchnic_blood_flow_in_the_rat_ L2 - http://www.physiology.org/doi/full/10.1152/ajpgi.1994.267.6.G1035?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -