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Use of serological markers as a screening test in family members of patients with celiac disease.
J Pediatr Gastroenterol Nutr 1994; 19(3):304-9JP

Abstract

That symptomatic celiac disease (CD) can occur in several members of a family has long been recognized. Given the possible complications of untreated CD, it is also important to diagnose those family members with "silent" disease, to offer them the benefit of a gluten-free diet. We studied 642 first-degree relatives of 210 patients with CD, two of the latter belonging to the same family. IgA and IgG antigliadin antibodies and IgA antiendomysium antibodies were studied in all. Jejunal biopsy was performed in 59 subjects, 47 with positive and 12 with negative serological markers. Celiac disease was diagnosed de novo in 18 cases (2.8%). Diagnosis in a symptomatic mother was made by jejunal biopsy despite the negativity of all immunological markers. We conclude that the risk of having CD is higher in siblings than in parents of patients with CD, that the most useful marker for diagnosis is the study of IgA antiendomysium antibodies, and that the absence of positive serological markers does not completely exclude the diagnosis of CD.

Authors+Show Affiliations

Department of Pediatrics, Hospital de Cruces, Bilbao, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7815262

Citation

Vitoria, J C., et al. "Use of Serological Markers as a Screening Test in Family Members of Patients With Celiac Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 19, no. 3, 1994, pp. 304-9.
Vitoria JC, Arrieta A, Astigarraga I, et al. Use of serological markers as a screening test in family members of patients with celiac disease. J Pediatr Gastroenterol Nutr. 1994;19(3):304-9.
Vitoria, J. C., Arrieta, A., Astigarraga, I., García-Masdevall, D., & Rodriguez-Soriano, J. (1994). Use of serological markers as a screening test in family members of patients with celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 19(3), pp. 304-9.
Vitoria JC, et al. Use of Serological Markers as a Screening Test in Family Members of Patients With Celiac Disease. J Pediatr Gastroenterol Nutr. 1994;19(3):304-9. PubMed PMID: 7815262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of serological markers as a screening test in family members of patients with celiac disease. AU - Vitoria,J C, AU - Arrieta,A, AU - Astigarraga,I, AU - García-Masdevall,D, AU - Rodriguez-Soriano,J, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 304 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 19 IS - 3 N2 - That symptomatic celiac disease (CD) can occur in several members of a family has long been recognized. Given the possible complications of untreated CD, it is also important to diagnose those family members with "silent" disease, to offer them the benefit of a gluten-free diet. We studied 642 first-degree relatives of 210 patients with CD, two of the latter belonging to the same family. IgA and IgG antigliadin antibodies and IgA antiendomysium antibodies were studied in all. Jejunal biopsy was performed in 59 subjects, 47 with positive and 12 with negative serological markers. Celiac disease was diagnosed de novo in 18 cases (2.8%). Diagnosis in a symptomatic mother was made by jejunal biopsy despite the negativity of all immunological markers. We conclude that the risk of having CD is higher in siblings than in parents of patients with CD, that the most useful marker for diagnosis is the study of IgA antiendomysium antibodies, and that the absence of positive serological markers does not completely exclude the diagnosis of CD. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/7815262/Use_of_serological_markers_as_a_screening_test_in_family_members_of_patients_with_celiac_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7815262.ui DB - PRIME DP - Unbound Medicine ER -