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Glutamine-enriched enteral diet increases renal arginine production.
JPEN J Parenter Enteral Nutr 1994 Sep-Oct; 18(5):422-6JJ

Abstract

BACKGROUND

Arginine (Arg) is generated in the kidney by the conversion of circulating citrulline. The most important source for circulating citrulline is the metabolism of glutamine (Gln) by the gut. In this study, we investigated the influence of an enteral diet enriched with Gln on renal Arg synthesis in the rat.

METHODS

Rats were fed a 12.5% Gln-enriched diet or an isocaloric, isonitrogenous control diet for 14 days. Kidney plasma flow and arterial and renal venous plasma levels of a number of amino acids were measured, and kidney amino acid fluxes were calculated.

RESULTS

Compared with the control diet, Gln enrichment resulted in significantly higher arterial plasma levels of circulating citrulline (30%, p < .0001) and Arg (31%, p < .0005). The uptake of circulating citrulline and the subsequent production of Arg by the kidneys were significantly higher in the Gln-enriched group (40% and 38%, respectively) and showed an equimolar relationship in both the control (r = .84, p < .0001) and the Gln-enriched group (r = .83, p < .0001).

CONCLUSIONS

The findings indicate that enteral Gln supplementation caused significantly increased arterial plasma levels of Arg as a result of increased renal Arg production from circulating citrulline. Considering the multiple important biologic properties of Arg, the reported beneficial effects of Gln in catabolic states might be explained in part by increased renal Arg production.

Authors+Show Affiliations

Department of Surgery, Free University Hospital, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7815673

Citation

Houdijk, A P., et al. "Glutamine-enriched Enteral Diet Increases Renal Arginine Production." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 18, no. 5, 1994, pp. 422-6.
Houdijk AP, van Leeuwen PA, Teerlink T, et al. Glutamine-enriched enteral diet increases renal arginine production. JPEN J Parenter Enteral Nutr. 1994;18(5):422-6.
Houdijk, A. P., van Leeuwen, P. A., Teerlink, T., Flinkerbusch, E. L., Boermeester, M. A., Sauerwein, H. P., & Wesdorp, R. I. (1994). Glutamine-enriched enteral diet increases renal arginine production. JPEN. Journal of Parenteral and Enteral Nutrition, 18(5), pp. 422-6.
Houdijk AP, et al. Glutamine-enriched Enteral Diet Increases Renal Arginine Production. JPEN J Parenter Enteral Nutr. 1994;18(5):422-6. PubMed PMID: 7815673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutamine-enriched enteral diet increases renal arginine production. AU - Houdijk,A P, AU - van Leeuwen,P A, AU - Teerlink,T, AU - Flinkerbusch,E L, AU - Boermeester,M A, AU - Sauerwein,H P, AU - Wesdorp,R I, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 422 EP - 6 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 18 IS - 5 N2 - BACKGROUND: Arginine (Arg) is generated in the kidney by the conversion of circulating citrulline. The most important source for circulating citrulline is the metabolism of glutamine (Gln) by the gut. In this study, we investigated the influence of an enteral diet enriched with Gln on renal Arg synthesis in the rat. METHODS: Rats were fed a 12.5% Gln-enriched diet or an isocaloric, isonitrogenous control diet for 14 days. Kidney plasma flow and arterial and renal venous plasma levels of a number of amino acids were measured, and kidney amino acid fluxes were calculated. RESULTS: Compared with the control diet, Gln enrichment resulted in significantly higher arterial plasma levels of circulating citrulline (30%, p < .0001) and Arg (31%, p < .0005). The uptake of circulating citrulline and the subsequent production of Arg by the kidneys were significantly higher in the Gln-enriched group (40% and 38%, respectively) and showed an equimolar relationship in both the control (r = .84, p < .0001) and the Gln-enriched group (r = .83, p < .0001). CONCLUSIONS: The findings indicate that enteral Gln supplementation caused significantly increased arterial plasma levels of Arg as a result of increased renal Arg production from circulating citrulline. Considering the multiple important biologic properties of Arg, the reported beneficial effects of Gln in catabolic states might be explained in part by increased renal Arg production. SN - 0148-6071 UR - https://www.unboundmedicine.com/medline/citation/7815673/Glutamine_enriched_enteral_diet_increases_renal_arginine_production_ L2 - https://doi.org/10.1177/0148607194018005422 DB - PRIME DP - Unbound Medicine ER -