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Bone mineral density of total body, spine, and femoral neck in children and young adults: a cross-sectional and longitudinal study.
J Bone Miner Res. 1994 Sep; 9(9):1451-8.JB

Abstract

Bone mineral density (BMD) of total body (TBMD), lumbar spine (L2-4), and femoral neck was measured in 266 normal subjects (136 males) aged 4-27 years (mean 13 years) using dual-energy x-ray absorptiometry (DXA). BMD of all sites increased significantly with age until 17.5 years in males and 15.8 years in females, except for femoral neck BMD in females, which peaked at age 14.1 years. Males had higher peak TBMD, which was attributed to greater weight and lean tissue mass. In contrast, despite a later timing, peak L2-4 BMD in males was not different from that in females. Before peak BMD, weight was the best predictor of TBMD and L2-4 BMD in both sexes (r2 ranged from 0.77 to 0.88), whereas femoral neck BMD was predicted equally by height and weight. Longitudinal information collected from 53 (25 boys) of these children, aged 4-16.9 years, showed that the average annualized gain in TBMD was 0.047 g/cm2 for boys and 0.039 g/cm2 for girls. No significant difference in the association between age and BMD (slopes) was found between cross-sectional and longitudinal data for either sex. We conclude that the timing for peak BMD was consistent for total body, lumbar spine, and femoral neck for each sex. The earlier peak BMD in females is most likely related to earlier puberty. The cross-sectional normative data of this study are useful in serving as a standard for serial assessment in health and disease states.

Authors+Show Affiliations

Robert Vines Growth Research Centre, Royal Alexandra Hospital for Children, Sydney, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7817830

Citation

Lu, P W., et al. "Bone Mineral Density of Total Body, Spine, and Femoral Neck in Children and Young Adults: a Cross-sectional and Longitudinal Study." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 9, no. 9, 1994, pp. 1451-8.
Lu PW, Briody JN, Ogle GD, et al. Bone mineral density of total body, spine, and femoral neck in children and young adults: a cross-sectional and longitudinal study. J Bone Miner Res. 1994;9(9):1451-8.
Lu, P. W., Briody, J. N., Ogle, G. D., Morley, K., Humphries, I. R., Allen, J., Howman-Giles, R., Sillence, D., & Cowell, C. T. (1994). Bone mineral density of total body, spine, and femoral neck in children and young adults: a cross-sectional and longitudinal study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 9(9), 1451-8.
Lu PW, et al. Bone Mineral Density of Total Body, Spine, and Femoral Neck in Children and Young Adults: a Cross-sectional and Longitudinal Study. J Bone Miner Res. 1994;9(9):1451-8. PubMed PMID: 7817830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density of total body, spine, and femoral neck in children and young adults: a cross-sectional and longitudinal study. AU - Lu,P W, AU - Briody,J N, AU - Ogle,G D, AU - Morley,K, AU - Humphries,I R, AU - Allen,J, AU - Howman-Giles,R, AU - Sillence,D, AU - Cowell,C T, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 1451 EP - 8 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 9 IS - 9 N2 - Bone mineral density (BMD) of total body (TBMD), lumbar spine (L2-4), and femoral neck was measured in 266 normal subjects (136 males) aged 4-27 years (mean 13 years) using dual-energy x-ray absorptiometry (DXA). BMD of all sites increased significantly with age until 17.5 years in males and 15.8 years in females, except for femoral neck BMD in females, which peaked at age 14.1 years. Males had higher peak TBMD, which was attributed to greater weight and lean tissue mass. In contrast, despite a later timing, peak L2-4 BMD in males was not different from that in females. Before peak BMD, weight was the best predictor of TBMD and L2-4 BMD in both sexes (r2 ranged from 0.77 to 0.88), whereas femoral neck BMD was predicted equally by height and weight. Longitudinal information collected from 53 (25 boys) of these children, aged 4-16.9 years, showed that the average annualized gain in TBMD was 0.047 g/cm2 for boys and 0.039 g/cm2 for girls. No significant difference in the association between age and BMD (slopes) was found between cross-sectional and longitudinal data for either sex. We conclude that the timing for peak BMD was consistent for total body, lumbar spine, and femoral neck for each sex. The earlier peak BMD in females is most likely related to earlier puberty. The cross-sectional normative data of this study are useful in serving as a standard for serial assessment in health and disease states. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/7817830/Bone_mineral_density_of_total_body_spine_and_femoral_neck_in_children_and_young_adults:_a_cross_sectional_and_longitudinal_study_ L2 - https://doi.org/10.1002/jbmr.5650090918 DB - PRIME DP - Unbound Medicine ER -