Tags

Type your tag names separated by a space and hit enter

The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease.
Ann Neurol. 1995 Jan; 37(1):110-2.AN

Abstract

Approximately one-fourth of neuropathologically confirmed cases of Alzheimer's disease (AD) also have brainstem and neocortical Lewy bodies, constituting a Lewy body variant of AD. Because Lewy bodies are a pathologic hallmark of Parkinson's disease (PD), this subpopulation of AD subjects may have the same risk factors as PD subjects. Analyses of the cytochrome P450 CYP2D6-debrisoquine 4-hydroxylase mutant B allele, a susceptibility gene for PD, revealed a higher representation of this allele in the Lewy body variant of AD than in pure AD or non-AD without Lewy bodies.

Authors+Show Affiliations

Department of Neurosciences, School of Medicine, UCSD, La Jolla 92093-0624.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7818242

Citation

Saitoh, T, et al. "The CYP2D6B Mutant Allele Is Overrepresented in the Lewy Body Variant of Alzheimer's Disease." Annals of Neurology, vol. 37, no. 1, 1995, pp. 110-2.
Saitoh T, Xia Y, Chen X, et al. The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease. Ann Neurol. 1995;37(1):110-2.
Saitoh, T., Xia, Y., Chen, X., Masliah, E., Galasko, D., Shults, C., Thal, L. J., Hansen, L. A., & Katzman, R. (1995). The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease. Annals of Neurology, 37(1), 110-2.
Saitoh T, et al. The CYP2D6B Mutant Allele Is Overrepresented in the Lewy Body Variant of Alzheimer's Disease. Ann Neurol. 1995;37(1):110-2. PubMed PMID: 7818242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease. AU - Saitoh,T, AU - Xia,Y, AU - Chen,X, AU - Masliah,E, AU - Galasko,D, AU - Shults,C, AU - Thal,L J, AU - Hansen,L A, AU - Katzman,R, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 110 EP - 2 JF - Annals of neurology JO - Ann Neurol VL - 37 IS - 1 N2 - Approximately one-fourth of neuropathologically confirmed cases of Alzheimer's disease (AD) also have brainstem and neocortical Lewy bodies, constituting a Lewy body variant of AD. Because Lewy bodies are a pathologic hallmark of Parkinson's disease (PD), this subpopulation of AD subjects may have the same risk factors as PD subjects. Analyses of the cytochrome P450 CYP2D6-debrisoquine 4-hydroxylase mutant B allele, a susceptibility gene for PD, revealed a higher representation of this allele in the Lewy body variant of AD than in pure AD or non-AD without Lewy bodies. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/7818242/The_CYP2D6B_mutant_allele_is_overrepresented_in_the_Lewy_body_variant_of_Alzheimer's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1995&volume=37&issue=1&spage=110 DB - PRIME DP - Unbound Medicine ER -