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Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats.
Arzneimittelforschung. 1994 Oct; 44(10):1105-7.A

Abstract

A stimulus cue of 1-amino-5-bromouracil (ABU, CAS 127984-93-4) was compared with that of diazepam (DZP) using a drug discrimination paradigm in rats. Groups of rats were trained to discriminate DZP (1 mg/kg i.p.) or ABU (20 mg/kg i.p.) from vehicle. Generalization of the cue of the trained drug to pentobarbital was shown in DZP- and ABU-trained rats at a dose of 5 mg/kg. The stimulus cue of ABU showed a tendency to generalize to DZP in ABU-trained rats but generalization of that of DZP to ABU in DZP-trained rats was only partial. Also partial generalization of that of DZP to imipramine and clonidine was found but not to 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) in DZP-trained rats. Full generalization of the stimulus cue of ABU to imipramine and partial generalization of that of ABU to clonidine and 8-OH-DPAT was observed in ABU-trained rats. The results suggest that the discriminative stimulus properties of ABU differ from those of DZP.

Authors+Show Affiliations

Biology Laboratory, Yamasa Corporation, Chiba, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7818580

Citation

Imaizumi, M, et al. "Discriminative Stimulus Properties of Diazepam and the Novel Anxiolytic Agent 1-amino-5-bromouracil in Rats." Arzneimittel-Forschung, vol. 44, no. 10, 1994, pp. 1105-7.
Imaizumi M, Miyazaki S, Machida H. Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats. Arzneimittelforschung. 1994;44(10):1105-7.
Imaizumi, M., Miyazaki, S., & Machida, H. (1994). Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats. Arzneimittel-Forschung, 44(10), 1105-7.
Imaizumi M, Miyazaki S, Machida H. Discriminative Stimulus Properties of Diazepam and the Novel Anxiolytic Agent 1-amino-5-bromouracil in Rats. Arzneimittelforschung. 1994;44(10):1105-7. PubMed PMID: 7818580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats. AU - Imaizumi,M, AU - Miyazaki,S, AU - Machida,H, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1105 EP - 7 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 44 IS - 10 N2 - A stimulus cue of 1-amino-5-bromouracil (ABU, CAS 127984-93-4) was compared with that of diazepam (DZP) using a drug discrimination paradigm in rats. Groups of rats were trained to discriminate DZP (1 mg/kg i.p.) or ABU (20 mg/kg i.p.) from vehicle. Generalization of the cue of the trained drug to pentobarbital was shown in DZP- and ABU-trained rats at a dose of 5 mg/kg. The stimulus cue of ABU showed a tendency to generalize to DZP in ABU-trained rats but generalization of that of DZP to ABU in DZP-trained rats was only partial. Also partial generalization of that of DZP to imipramine and clonidine was found but not to 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) in DZP-trained rats. Full generalization of the stimulus cue of ABU to imipramine and partial generalization of that of ABU to clonidine and 8-OH-DPAT was observed in ABU-trained rats. The results suggest that the discriminative stimulus properties of ABU differ from those of DZP. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/7818580/Discriminative_stimulus_properties_of_diazepam_and_the_novel_anxiolytic_agent_1_amino_5_bromouracil_in_rats_ DB - PRIME DP - Unbound Medicine ER -