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The relation between biliary lipids, nucleation time, and number of gallbladder stones after percutaneous gallbladder puncture.
Scand J Gastroenterol 1994; 29(9):844-8SJ

Abstract

BACKGROUND

Biliary lipids and nucleation time are increasingly of importance in the understanding of the cholesterol nucleation process in gallstone patients.

METHODS

Biliary lipids, total lipid concentration (TLC), cholesterol saturation index (CSI) and nucleation time (NT) were studied in 221 bile samples from patients with solitary (n = 120) and multiple (n = 101) gallbladder stones.

RESULTS

Biliary cholesterol concentration and CSI did not differ between patients with solitary or multiple stones; however, it was positively correlated with the CSI (r = 0.93; p < 0.01). We found a negative correlation between CSI and TLC (r = -0.77 for solitary stones and r = -0.79 for multiple stones; p < 0.01). Furthermore, levels of total bile acids and phospholipids were similar in cases with solitary and multiple gallbladder stones. TLC did not correlate with single or multiple stones, whereas NT was determined to be negatively correlated with the number of gallstones (r = -0.39; p < 0.01). Patients with solitary stones had a significantly (p < 0.01) longer NT than those with multiple gallbladder stones (7.5 +/- 4.2 days versus 2.3 +/- 1.5 days).

CONCLUSIONS

Our findings suggest that there exists a nucleation-promoting activity, which seems to be more pronounced in patients with multiple gallbladder stones than in those with solitary stones, indicating a major risk factor for the higher recurrence rate seen in these patients.

Authors+Show Affiliations

Dept. of Internal Medicine, Krankenhaus der Barmherzigen Brüder, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7824866

Citation

Tudyka, J, et al. "The Relation Between Biliary Lipids, Nucleation Time, and Number of Gallbladder Stones After Percutaneous Gallbladder Puncture." Scandinavian Journal of Gastroenterology, vol. 29, no. 9, 1994, pp. 844-8.
Tudyka J, Kratzer W, Maier C, et al. The relation between biliary lipids, nucleation time, and number of gallbladder stones after percutaneous gallbladder puncture. Scand J Gastroenterol. 1994;29(9):844-8.
Tudyka, J., Kratzer, W., Maier, C., Mason, R., & Wechsler, J. G. (1994). The relation between biliary lipids, nucleation time, and number of gallbladder stones after percutaneous gallbladder puncture. Scandinavian Journal of Gastroenterology, 29(9), pp. 844-8.
Tudyka J, et al. The Relation Between Biliary Lipids, Nucleation Time, and Number of Gallbladder Stones After Percutaneous Gallbladder Puncture. Scand J Gastroenterol. 1994;29(9):844-8. PubMed PMID: 7824866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation between biliary lipids, nucleation time, and number of gallbladder stones after percutaneous gallbladder puncture. AU - Tudyka,J, AU - Kratzer,W, AU - Maier,C, AU - Mason,R, AU - Wechsler,J G, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 844 EP - 8 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 29 IS - 9 N2 - BACKGROUND: Biliary lipids and nucleation time are increasingly of importance in the understanding of the cholesterol nucleation process in gallstone patients. METHODS: Biliary lipids, total lipid concentration (TLC), cholesterol saturation index (CSI) and nucleation time (NT) were studied in 221 bile samples from patients with solitary (n = 120) and multiple (n = 101) gallbladder stones. RESULTS: Biliary cholesterol concentration and CSI did not differ between patients with solitary or multiple stones; however, it was positively correlated with the CSI (r = 0.93; p < 0.01). We found a negative correlation between CSI and TLC (r = -0.77 for solitary stones and r = -0.79 for multiple stones; p < 0.01). Furthermore, levels of total bile acids and phospholipids were similar in cases with solitary and multiple gallbladder stones. TLC did not correlate with single or multiple stones, whereas NT was determined to be negatively correlated with the number of gallstones (r = -0.39; p < 0.01). Patients with solitary stones had a significantly (p < 0.01) longer NT than those with multiple gallbladder stones (7.5 +/- 4.2 days versus 2.3 +/- 1.5 days). CONCLUSIONS: Our findings suggest that there exists a nucleation-promoting activity, which seems to be more pronounced in patients with multiple gallbladder stones than in those with solitary stones, indicating a major risk factor for the higher recurrence rate seen in these patients. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/7824866/The_relation_between_biliary_lipids_nucleation_time_and_number_of_gallbladder_stones_after_percutaneous_gallbladder_puncture_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365529409092521 DB - PRIME DP - Unbound Medicine ER -