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Iron absorption from the whole diet: comparison of the effect of two different distributions of daily calcium intake.
Am J Clin Nutr. 1995 Jan; 61(1):97-104.AJ

Abstract

The possibility of reducing calcium inhibition of iron absorption by decreasing calcium intake in lunch and dinner meals, which provided the most dietary iron, was examined in 21 healthy female volunteers. During a 10-d period, nonheme iron in all meals was extrinsically labeled with radioisotopic iron to a uniform specific activity. Iron absorption from two identical 10-d periods was compared when meals were labeled with two different iron radioisotopes and when the same amount of calcium (937 mg) was distributed in two ways, in either mainly breakfast and late evening meals or more evenly in all meals. About 30-50% more iron was absorbed when no milk or cheese was served with lunch or dinner. The difference was statistically significant. Median iron requirements (1.61 mg/d) calculated from body weight and menstrual iron losses agreed with the mean value of median iron absorption in the two 10-d periods (1.54 mg/d), which supports the validity of the present method. A reasonable separation of calcium and iron intakes would improve iron nutrition.

Authors+Show Affiliations

Department of Internal Medicine, University of Göteborg, Annedalsklinikerna, Sahlgren's Hospital, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7825544

Citation

Gleerup, A, et al. "Iron Absorption From the Whole Diet: Comparison of the Effect of Two Different Distributions of Daily Calcium Intake." The American Journal of Clinical Nutrition, vol. 61, no. 1, 1995, pp. 97-104.
Gleerup A, Rossander-Hulthén L, Gramatkovski E, et al. Iron absorption from the whole diet: comparison of the effect of two different distributions of daily calcium intake. Am J Clin Nutr. 1995;61(1):97-104.
Gleerup, A., Rossander-Hulthén, L., Gramatkovski, E., & Hallberg, L. (1995). Iron absorption from the whole diet: comparison of the effect of two different distributions of daily calcium intake. The American Journal of Clinical Nutrition, 61(1), 97-104.
Gleerup A, et al. Iron Absorption From the Whole Diet: Comparison of the Effect of Two Different Distributions of Daily Calcium Intake. Am J Clin Nutr. 1995;61(1):97-104. PubMed PMID: 7825544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron absorption from the whole diet: comparison of the effect of two different distributions of daily calcium intake. AU - Gleerup,A, AU - Rossander-Hulthén,L, AU - Gramatkovski,E, AU - Hallberg,L, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 97 EP - 104 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 61 IS - 1 N2 - The possibility of reducing calcium inhibition of iron absorption by decreasing calcium intake in lunch and dinner meals, which provided the most dietary iron, was examined in 21 healthy female volunteers. During a 10-d period, nonheme iron in all meals was extrinsically labeled with radioisotopic iron to a uniform specific activity. Iron absorption from two identical 10-d periods was compared when meals were labeled with two different iron radioisotopes and when the same amount of calcium (937 mg) was distributed in two ways, in either mainly breakfast and late evening meals or more evenly in all meals. About 30-50% more iron was absorbed when no milk or cheese was served with lunch or dinner. The difference was statistically significant. Median iron requirements (1.61 mg/d) calculated from body weight and menstrual iron losses agreed with the mean value of median iron absorption in the two 10-d periods (1.54 mg/d), which supports the validity of the present method. A reasonable separation of calcium and iron intakes would improve iron nutrition. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/7825544/Iron_absorption_from_the_whole_diet:_comparison_of_the_effect_of_two_different_distributions_of_daily_calcium_intake_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/61.1.97 DB - PRIME DP - Unbound Medicine ER -