Tags

Type your tag names separated by a space and hit enter

[Effect of combination therapy with disodium cromoglycate (DSCG) and Ozagrel on non-atopic asthmatics].
Arerugi 1994; 43(10):1262-9A

Abstract

Ozagrel (OKY-046), a selective inhibitor of thromboxane biosynthesis has been reported to reduce airway hyperresponsiveness in asthmatics. DSCG has been widely used for atopic, but not for non-atopic asthmatics. We evaluated the additive effect of combination therapy with DSCG and Ozagrel on nonatopic asthmatics. Fourteen asthmatics were divided into two groups. The patients in the O-D group were initially treated with Ozagrel (400 mg/day) for 4 weeks, and then DSCG (8 mg/day) was added for another 4 weeks. The patients in D-O group were initially treated with DSCG (8 mg/day), and then Ozagrel (400 mg/day) was added for 4 more weeks. TXB2, PGF2 alpha, PGE2, 6-keto-PGF1 alpha in sputum and 11-dehydro TXB2 in urine were measured before and after 4th and 8th weeks of therapy. Ozagrel decreased the metabolites of thromboxane and PGF2 alpha in sputum and urine. PGE2 in sputum tended to be increased by Ozagrel. DSCG did not affect mediators in sputum. Combination therapy with Ozagrel and DSCG showed the additive effect to single use on attack score and PF in non-atopic asthmatics.

Authors+Show Affiliations

First Department of Internal Medicine, Nihon University School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

jpn

PubMed ID

7826222

Citation

Yoshida, N, et al. "[Effect of Combination Therapy With Disodium Cromoglycate (DSCG) and Ozagrel On Non-atopic Asthmatics]." Arerugi = [Allergy], vol. 43, no. 10, 1994, pp. 1262-9.
Yoshida N, Suguro H, Hashimoto N, et al. [Effect of combination therapy with disodium cromoglycate (DSCG) and Ozagrel on non-atopic asthmatics]. Arerugi. 1994;43(10):1262-9.
Yoshida, N., Suguro, H., Hashimoto, N., Majima, T., Yamaguchi, M., & Horie, T. (1994). [Effect of combination therapy with disodium cromoglycate (DSCG) and Ozagrel on non-atopic asthmatics]. Arerugi = [Allergy], 43(10), pp. 1262-9.
Yoshida N, et al. [Effect of Combination Therapy With Disodium Cromoglycate (DSCG) and Ozagrel On Non-atopic Asthmatics]. Arerugi. 1994;43(10):1262-9. PubMed PMID: 7826222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of combination therapy with disodium cromoglycate (DSCG) and Ozagrel on non-atopic asthmatics]. AU - Yoshida,N, AU - Suguro,H, AU - Hashimoto,N, AU - Majima,T, AU - Yamaguchi,M, AU - Horie,T, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1262 EP - 9 JF - Arerugi = [Allergy] JO - Arerugi VL - 43 IS - 10 N2 - Ozagrel (OKY-046), a selective inhibitor of thromboxane biosynthesis has been reported to reduce airway hyperresponsiveness in asthmatics. DSCG has been widely used for atopic, but not for non-atopic asthmatics. We evaluated the additive effect of combination therapy with DSCG and Ozagrel on nonatopic asthmatics. Fourteen asthmatics were divided into two groups. The patients in the O-D group were initially treated with Ozagrel (400 mg/day) for 4 weeks, and then DSCG (8 mg/day) was added for another 4 weeks. The patients in D-O group were initially treated with DSCG (8 mg/day), and then Ozagrel (400 mg/day) was added for 4 more weeks. TXB2, PGF2 alpha, PGE2, 6-keto-PGF1 alpha in sputum and 11-dehydro TXB2 in urine were measured before and after 4th and 8th weeks of therapy. Ozagrel decreased the metabolites of thromboxane and PGF2 alpha in sputum and urine. PGE2 in sputum tended to be increased by Ozagrel. DSCG did not affect mediators in sputum. Combination therapy with Ozagrel and DSCG showed the additive effect to single use on attack score and PF in non-atopic asthmatics. SN - 0021-4884 UR - https://www.unboundmedicine.com/medline/citation/7826222/[Effect_of_combination_therapy_with_disodium_cromoglycate__DSCG__and_Ozagrel_on_non_atopic_asthmatics]_ L2 - https://medlineplus.gov/coldandcoughmedicines.html DB - PRIME DP - Unbound Medicine ER -