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Epidural opioid analgesia after caesarean section: a comparison of patient-controlled analgesia with meperidine and single bolus injection of morphine.
Can J Anaesth. 1994 Nov; 41(11):1063-8.CJ

Abstract

The quality of analgesia, patient satisfaction and incidence of side effects following a single bolus of epidural morphine were compared with patient-controlled epidural analgesia (PCEA) with meperidine during the first 24 hr after elective Caesarean section. Seventy-five women were randomly assigned to three equal groups. Group I received 30 mg epidural meperidine after delivery and PCEA with meperidine; Group 2 received 3 mg epidural morphine after delivery and PCEA with saline in a double-blind fashion. Group 3 received 3 mg epidural morphine after delivery without saline PCEA. Visual analogue pain scores (VAS) were higher with PCEA meperidine from 8-16 hr post-operatively (P < 0.05) than in both epidural morphine groups. Two patients in Group 1 and one in Group 3 required supplemental parental analgesia. The incidence of nausea was 16% in Group 1, compared with 52% in Group 2 and 56% in Group 3 (P < 0.01). Pruritus occurred in 24% of Group 1 patients, 84% of patients in Group 2 and 68% of patients in Group 3 (P < 0.001). Forty-six percent of patients in Group 1 were very satisfied with pain management, compared with 77% in Group 2 and 79% in Group 3. Nurse workload was higher in the PCEA study groups than in Group 3 (P < 0.05). A single bolus of epidural morphine provides superior analgesia and satisfaction at low cost, but with a higher incidence of nausea and pruritus than PCEA with meperidine.

Authors+Show Affiliations

Rosaeg OP
Department of Anaesthesia, Ottawa Civic Hospital, University of Ottawa, Ontario.
Lindsay MP
No affiliation info available

MeSH

AdultAnalgesia, EpiduralAnalgesia, ObstetricalAnalgesia, Patient-ControlledCesarean SectionDouble-Blind MethodElective Surgical ProceduresFemaleHumansInjections, IntramuscularInjections, IntravenousMeperidineMorphineNauseaPain MeasurementPain, PostoperativePatient SatisfactionPregnancyPruritus

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7828253

Citation

Rosaeg, O P., and M P. Lindsay. "Epidural Opioid Analgesia After Caesarean Section: a Comparison of Patient-controlled Analgesia With Meperidine and Single Bolus Injection of Morphine." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 41, no. 11, 1994, pp. 1063-8.
Rosaeg OP, Lindsay MP. Epidural opioid analgesia after caesarean section: a comparison of patient-controlled analgesia with meperidine and single bolus injection of morphine. Can J Anaesth. 1994;41(11):1063-8.
Rosaeg, O. P., & Lindsay, M. P. (1994). Epidural opioid analgesia after caesarean section: a comparison of patient-controlled analgesia with meperidine and single bolus injection of morphine. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 41(11), 1063-8.
Rosaeg OP, Lindsay MP. Epidural Opioid Analgesia After Caesarean Section: a Comparison of Patient-controlled Analgesia With Meperidine and Single Bolus Injection of Morphine. Can J Anaesth. 1994;41(11):1063-8. PubMed PMID: 7828253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidural opioid analgesia after caesarean section: a comparison of patient-controlled analgesia with meperidine and single bolus injection of morphine. AU - Rosaeg,O P, AU - Lindsay,M P, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 1063 EP - 8 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 41 IS - 11 N2 - The quality of analgesia, patient satisfaction and incidence of side effects following a single bolus of epidural morphine were compared with patient-controlled epidural analgesia (PCEA) with meperidine during the first 24 hr after elective Caesarean section. Seventy-five women were randomly assigned to three equal groups. Group I received 30 mg epidural meperidine after delivery and PCEA with meperidine; Group 2 received 3 mg epidural morphine after delivery and PCEA with saline in a double-blind fashion. Group 3 received 3 mg epidural morphine after delivery without saline PCEA. Visual analogue pain scores (VAS) were higher with PCEA meperidine from 8-16 hr post-operatively (P < 0.05) than in both epidural morphine groups. Two patients in Group 1 and one in Group 3 required supplemental parental analgesia. The incidence of nausea was 16% in Group 1, compared with 52% in Group 2 and 56% in Group 3 (P < 0.01). Pruritus occurred in 24% of Group 1 patients, 84% of patients in Group 2 and 68% of patients in Group 3 (P < 0.001). Forty-six percent of patients in Group 1 were very satisfied with pain management, compared with 77% in Group 2 and 79% in Group 3. Nurse workload was higher in the PCEA study groups than in Group 3 (P < 0.05). A single bolus of epidural morphine provides superior analgesia and satisfaction at low cost, but with a higher incidence of nausea and pruritus than PCEA with meperidine. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/7828253/Epidural_opioid_analgesia_after_caesarean_section:_a_comparison_of_patient_controlled_analgesia_with_meperidine_and_single_bolus_injection_of_morphine_ L2 - https://doi.org/10.1007/BF03015655 DB - PRIME DP - Unbound Medicine ER -