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d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release.
Eur J Pharmacol. 1994 Oct 13; 264(1):111-5.EJ

Abstract

d-Fenfluramine (2.5 mg/kg i.p.) caused marked hypophagia in food-deprived rats and significantly increased medial hypothalamic extracellular 5-hydroxytryptamine (5-HT) as indicated by in vivo microdialysis. When the drug was given after the 5-HT synthesis inhibitor p-chlorophenylalanine (150 mg/kg per day x 3) the hypophagic response was unimpaired but dialysate 5-HT concentration no longer rose. The d-fenfluramine metabolite d-norfenfluramine (1.5 mg/kg i.p.) caused slightly greater hypophagia than the parent drug and completely blocked feeding in animals pretreated with p-chlorophenylalanine, but dialysate 5-HT was increased in neither circumstance. The results provide evidence against mediation of the hypophagic effects of d-fenfluramine and d-norfenfluramine by increased availability of 5-HT to receptors.

Authors+Show Affiliations

Department of Neurochemistry, Institute of Neurology, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7828639

Citation

Oluyomi, A O., et al. "D-Fenfluramine and D-norfenfluramine Hypophagias Do Not Require Increased Hypothalamic 5-hydroxytryptamine Release." European Journal of Pharmacology, vol. 264, no. 1, 1994, pp. 111-5.
Oluyomi AO, Gibson EL, Barnfield AM, et al. D-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release. Eur J Pharmacol. 1994;264(1):111-5.
Oluyomi, A. O., Gibson, E. L., Barnfield, A. M., & Curzon, G. (1994). D-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release. European Journal of Pharmacology, 264(1), 111-5.
Oluyomi AO, et al. D-Fenfluramine and D-norfenfluramine Hypophagias Do Not Require Increased Hypothalamic 5-hydroxytryptamine Release. Eur J Pharmacol. 1994 Oct 13;264(1):111-5. PubMed PMID: 7828639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release. AU - Oluyomi,A O, AU - Gibson,E L, AU - Barnfield,A M, AU - Curzon,G, PY - 1994/10/13/pubmed PY - 1994/10/13/medline PY - 1994/10/13/entrez SP - 111 EP - 5 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 264 IS - 1 N2 - d-Fenfluramine (2.5 mg/kg i.p.) caused marked hypophagia in food-deprived rats and significantly increased medial hypothalamic extracellular 5-hydroxytryptamine (5-HT) as indicated by in vivo microdialysis. When the drug was given after the 5-HT synthesis inhibitor p-chlorophenylalanine (150 mg/kg per day x 3) the hypophagic response was unimpaired but dialysate 5-HT concentration no longer rose. The d-fenfluramine metabolite d-norfenfluramine (1.5 mg/kg i.p.) caused slightly greater hypophagia than the parent drug and completely blocked feeding in animals pretreated with p-chlorophenylalanine, but dialysate 5-HT was increased in neither circumstance. The results provide evidence against mediation of the hypophagic effects of d-fenfluramine and d-norfenfluramine by increased availability of 5-HT to receptors. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/7828639/d_Fenfluramine_and_d_norfenfluramine_hypophagias_do_not_require_increased_hypothalamic_5_hydroxytryptamine_release_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(94)90646-7 DB - PRIME DP - Unbound Medicine ER -