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Attempts at perfect normalization of glucose tolerance test of severe diabetics by artificial beta cell.

Abstract

The artificial beta cell is a Glucose Controlled Insulin (and dextrose) Infusion System (GCIIS) for maintaining normoglycemia in diabetic conditions and other disturbances of metabolism. The insulin and dextrose infusion rates are calculated by a microcomputer according to the static glucose concentration (proportional control) and to its rate of change (dynamic control). The algorithms controlling the computer can be adapted to the subjects' requirements. It has already been shown, that the artificial beta cell is able to maintain blood sugar values in diabetics within physiological ranges during the course of the day. In our present study we examined the response of the artificial beta cell using a 100 gm oral glucose load in severe diabetics. The first type of control algorithms applied effected a rather small initial insulin infusion following OGTT in 8 juvenile diabetics connected with the artificial beta cell. The glucose responses thus obtained were similar to latent diabetes. In contrast, when the computer was controlled by the second type of algorithms with a more responsive dynamic control and a consequently higher initial insulin infusion, in one diabetic OGTT was fully normalized, whereas an improvement was achieved in another diabetic patient. Furthermore it was shown that control algorithms must be varied individually, depending on residual beta cell function and glucose regulatory mechanisms.

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    MeSH

    Blood Glucose
    Computers
    Diabetes Mellitus, Type 1
    Glucose Tolerance Test
    Humans
    Insulin
    Islets of Langerhans

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    783030

    Citation

    TY - JOUR T1 - Attempts at perfect normalization of glucose tolerance test of severe diabetics by artificial beta cell. AU - Kerner,W, AU - Thum,C, AU - Tamás,G, AU - Beischer,W, AU - Clemens,A H, AU - Pfeiffer,E F, PY - 1976/7/1/pubmed PY - 1976/7/1/medline PY - 1976/7/1/entrez SP - 256 EP - 61 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 8 IS - 4 N2 - The artificial beta cell is a Glucose Controlled Insulin (and dextrose) Infusion System (GCIIS) for maintaining normoglycemia in diabetic conditions and other disturbances of metabolism. The insulin and dextrose infusion rates are calculated by a microcomputer according to the static glucose concentration (proportional control) and to its rate of change (dynamic control). The algorithms controlling the computer can be adapted to the subjects' requirements. It has already been shown, that the artificial beta cell is able to maintain blood sugar values in diabetics within physiological ranges during the course of the day. In our present study we examined the response of the artificial beta cell using a 100 gm oral glucose load in severe diabetics. The first type of control algorithms applied effected a rather small initial insulin infusion following OGTT in 8 juvenile diabetics connected with the artificial beta cell. The glucose responses thus obtained were similar to latent diabetes. In contrast, when the computer was controlled by the second type of algorithms with a more responsive dynamic control and a consequently higher initial insulin infusion, in one diabetic OGTT was fully normalized, whereas an improvement was achieved in another diabetic patient. Furthermore it was shown that control algorithms must be varied individually, depending on residual beta cell function and glucose regulatory mechanisms. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/783030/abstract/Attempts_at_perfect_normalization_of_glucose_tolerance_test_of_severe_diabetics_by_artificial_beta_cell_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1093650 ER -