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Vitamin B12 metabolism and status during pregnancy, lactation and infancy.
Adv Exp Med Biol 1994; 352:173-86AE

Abstract

This overview of vitamin B12 metabolism and requirements during the continuum of pregnancy and lactation has identified several gaps in our knowledge. More information is needed concerning the roles of the different transcobalamins during pregnancy and lactation, including their impact on placental and mammary transfer of cobalamin and their effect on intestinal absorption in the infant. Knowledge is needed about the relative importance of maternal stores and current dietary intake on fetal storage of the vitamin, and on its concentration in breast milk. Because there is some evidence that infant's urinary methylmalonic acid excretion is reduced by intakes slightly higher than the current RDA, the adequacy of the current RDA for vitamin B12 during infancy should be verified. Finally, it is possible that vitamin B12 deficiency is more common in pregnant and lactating women and their young children in developing countries than has been recognized previously, due primarily to malabsorption. It is important to confirm whether or not this is the case, in view of its potential impact on infant neurobehavioral development and the relative ease with which supplements of the vitamin could be provided.

Authors+Show Affiliations

Department of Nutritional Sciences, University of Connecticut, Storrs 06269-4017.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7832046

Citation

Allen, L H.. "Vitamin B12 Metabolism and Status During Pregnancy, Lactation and Infancy." Advances in Experimental Medicine and Biology, vol. 352, 1994, pp. 173-86.
Allen LH. Vitamin B12 metabolism and status during pregnancy, lactation and infancy. Adv Exp Med Biol. 1994;352:173-86.
Allen, L. H. (1994). Vitamin B12 metabolism and status during pregnancy, lactation and infancy. Advances in Experimental Medicine and Biology, 352, pp. 173-86.
Allen LH. Vitamin B12 Metabolism and Status During Pregnancy, Lactation and Infancy. Adv Exp Med Biol. 1994;352:173-86. PubMed PMID: 7832046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 metabolism and status during pregnancy, lactation and infancy. A1 - Allen,L H, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez KW - Biology KW - Demographic Factors KW - Diet KW - Health KW - Human Milk KW - Infant Nutrition KW - Lactation KW - Literature Review KW - Maternal Physiology KW - Metabolic Effects KW - Nutrition KW - Physiology KW - Population KW - Population Characteristics KW - Pregnant Women KW - Vitamin B Complex KW - Vitamins SP - 173 EP - 86 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 352 N2 - This overview of vitamin B12 metabolism and requirements during the continuum of pregnancy and lactation has identified several gaps in our knowledge. More information is needed concerning the roles of the different transcobalamins during pregnancy and lactation, including their impact on placental and mammary transfer of cobalamin and their effect on intestinal absorption in the infant. Knowledge is needed about the relative importance of maternal stores and current dietary intake on fetal storage of the vitamin, and on its concentration in breast milk. Because there is some evidence that infant's urinary methylmalonic acid excretion is reduced by intakes slightly higher than the current RDA, the adequacy of the current RDA for vitamin B12 during infancy should be verified. Finally, it is possible that vitamin B12 deficiency is more common in pregnant and lactating women and their young children in developing countries than has been recognized previously, due primarily to malabsorption. It is important to confirm whether or not this is the case, in view of its potential impact on infant neurobehavioral development and the relative ease with which supplements of the vitamin could be provided. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/7832046/Vitamin_B12_metabolism_and_status_during_pregnancy_lactation_and_infancy_ L2 - https://ClinicalTrials.gov/search/term=7832046 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -