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[Urinary gonadotropin fragment measurement in the monitoring of trophoblastic disease].
Zhonghua Fu Chan Ke Za Zhi. 1994 Aug; 29(8):475-7, 510-1.ZF

Abstract

Urinary gonadotropin fragment (UGF) is a small peptide which is present in the urine of pregnant women and of women with trophoblastic diseases as well as with certain nontrophoblastic malignancies. 275 samples each of urine and blood from 46 patients with trophoblastic diseases were taken for UGF and hCG measurements and compared. 24 samples from 12 healthy, nonpregnant women were taken as control. Cut-off values of UGF and hCG used for measuring the sensitivity of trophoblastic diseases were respectively > 0.2 microgram/L and above 20 micrograms/L. It was found that 64.0% of the urine samples gave UGF values > 0.2 microgram/L and 66.5% of the blood samples showed hCG levels above 20 micrograms/L (P > 0.1). No false-positive rate was observed in the control group. However, among patients who were found to have low or negative hCG values, 57.6% showed positive UGF levels. These findings suggest that in patients with positive levels of both UGF and hCG, the UGF measurement may not be necessary. But for patients with low or negative blood hCG values, certain percentage of urine UGF could still be detected.

Authors+Show Affiliations

General Hospital of PLA, Beijing.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

chi

PubMed ID

7835119

Citation

Fu, C Y., et al. "[Urinary Gonadotropin Fragment Measurement in the Monitoring of Trophoblastic Disease]." Zhonghua Fu Chan Ke Za Zhi, vol. 29, no. 8, 1994, pp. 475-7, 510-1.
Fu CY, Cole LA, Kardana A. [Urinary gonadotropin fragment measurement in the monitoring of trophoblastic disease]. Zhonghua Fu Chan Ke Za Zhi. 1994;29(8):475-7, 510-1.
Fu, C. Y., Cole, L. A., & Kardana, A. (1994). [Urinary gonadotropin fragment measurement in the monitoring of trophoblastic disease]. Zhonghua Fu Chan Ke Za Zhi, 29(8), 475-7, 510-1.
Fu CY, Cole LA, Kardana A. [Urinary Gonadotropin Fragment Measurement in the Monitoring of Trophoblastic Disease]. Zhonghua Fu Chan Ke Za Zhi. 1994;29(8):475-7, 510-1. PubMed PMID: 7835119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Urinary gonadotropin fragment measurement in the monitoring of trophoblastic disease]. AU - Fu,C Y, AU - Cole,L A, AU - Kardana,A, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 475-7, 510-1 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 29 IS - 8 N2 - Urinary gonadotropin fragment (UGF) is a small peptide which is present in the urine of pregnant women and of women with trophoblastic diseases as well as with certain nontrophoblastic malignancies. 275 samples each of urine and blood from 46 patients with trophoblastic diseases were taken for UGF and hCG measurements and compared. 24 samples from 12 healthy, nonpregnant women were taken as control. Cut-off values of UGF and hCG used for measuring the sensitivity of trophoblastic diseases were respectively > 0.2 microgram/L and above 20 micrograms/L. It was found that 64.0% of the urine samples gave UGF values > 0.2 microgram/L and 66.5% of the blood samples showed hCG levels above 20 micrograms/L (P > 0.1). No false-positive rate was observed in the control group. However, among patients who were found to have low or negative hCG values, 57.6% showed positive UGF levels. These findings suggest that in patients with positive levels of both UGF and hCG, the UGF measurement may not be necessary. But for patients with low or negative blood hCG values, certain percentage of urine UGF could still be detected. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/7835119/[Urinary_gonadotropin_fragment_measurement_in_the_monitoring_of_trophoblastic_disease]_ L2 - https://medlineplus.gov/uterinecancer.html DB - PRIME DP - Unbound Medicine ER -