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Textural differences between AA and SS blood specimens as detected by image analysis.
Cytometry 1994; 17(2):167-72C

Abstract

High-resolution image analysis was employed in the analysis of round (discoid) erythrocytes from hematologically normal (AA) individuals, AA individuals with nonspecific anemia, individuals with sickle cell trait (AS), individuals with SC disease (SC), and individuals with sickle cell anemia (SS). The shape feature Form Factor (4 pi Area/Perimeter2) was used to select round cells and to exclude sickle and other abnormal cells. Textural features extracted from round cells of SS and SC patients were found to differ from those derived from cells of normal andanemic AA individuals. Two textural features, Standard Deviation of Run Length Matrix Counts and Rotation Moment of the Cooccurrence Matrix, discriminated between patients mean values from AA samples and those from SS samples. The ability of textural features to separate round cells into classes based on genotype suggests that high resolution image analysis may be an effective tool in the study and monitoring of sickle cell disease.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7835167

Citation

Robinson, R D., et al. "Textural Differences Between AA and SS Blood Specimens as Detected By Image Analysis." Cytometry, vol. 17, no. 2, 1994, pp. 167-72.
Robinson RD, Benjamin LJ, Cosgriff JM, et al. Textural differences between AA and SS blood specimens as detected by image analysis. Cytometry. 1994;17(2):167-72.
Robinson, R. D., Benjamin, L. J., Cosgriff, J. M., Cox, C., Lapets, O. P., Rowley, P. T., ... Wheeless, L. L. (1994). Textural differences between AA and SS blood specimens as detected by image analysis. Cytometry, 17(2), pp. 167-72.
Robinson RD, et al. Textural Differences Between AA and SS Blood Specimens as Detected By Image Analysis. Cytometry. 1994 Oct 1;17(2):167-72. PubMed PMID: 7835167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Textural differences between AA and SS blood specimens as detected by image analysis. AU - Robinson,R D, AU - Benjamin,L J, AU - Cosgriff,J M, AU - Cox,C, AU - Lapets,O P, AU - Rowley,P T, AU - Yatco,E, AU - Wheeless,L L, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 167 EP - 72 JF - Cytometry JO - Cytometry VL - 17 IS - 2 N2 - High-resolution image analysis was employed in the analysis of round (discoid) erythrocytes from hematologically normal (AA) individuals, AA individuals with nonspecific anemia, individuals with sickle cell trait (AS), individuals with SC disease (SC), and individuals with sickle cell anemia (SS). The shape feature Form Factor (4 pi Area/Perimeter2) was used to select round cells and to exclude sickle and other abnormal cells. Textural features extracted from round cells of SS and SC patients were found to differ from those derived from cells of normal andanemic AA individuals. Two textural features, Standard Deviation of Run Length Matrix Counts and Rotation Moment of the Cooccurrence Matrix, discriminated between patients mean values from AA samples and those from SS samples. The ability of textural features to separate round cells into classes based on genotype suggests that high resolution image analysis may be an effective tool in the study and monitoring of sickle cell disease. SN - 0196-4763 UR - https://www.unboundmedicine.com/medline/citation/7835167/Textural_differences_between_AA_and_SS_blood_specimens_as_detected_by_image_analysis_ L2 - https://doi.org/10.1002/cyto.990170209 DB - PRIME DP - Unbound Medicine ER -