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Metabolic bone assessment in patients with inflammatory bowel disease.
Gastroenterology 1995; 108(2):417-22G

Abstract

BACKGROUND/AIMS

Patients with inflammatory bowel disease are at risk for osteopenia. To study the metabolic bone status of these patients, a cross-sectional study was conducted.

METHODS

Eighty-four patients (49 women, 35 men) with inflammatory bowel disease, 34 of whom had Crohn's disease and 50 ulcerative colitis (including 18 with prior coloproctectomy and ileoanal anastomosis), underwent clinical, dietary, and spine radiological assessments. Bone metabolism was assessed by measuring serum levels of calcium, phosphate, parathyroid hormone (1-84), 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, and osteocalcin. Lumbar and femoral neck bone mineral densities were measured by dual energy X-ray absorptiometry.

RESULTS

Serum osteocalcin level was decreased in 29 patients (34%), 12 of whom had never undergone steroid therapy. The other biochemical markers of bone metabolism were in the normal range. Thirty-six patients (43%) had osteopenia, and 6 patients (7%) had vertebral crush fractures. Osteopenia was observed in 27 patients (52%) and 9 patients (28%) with and without corticosteroid therapy, respectively. No patient had clinical or biological signs of osteomalacia. Analysis of bone density (lumbar Z score) by a multiple regression analysis showed a statistically significant correlation with age, cumulative corticosteroid doses, sedimentation rate, and osteocalcin level (R2 = 0.76; P = 0.05).

CONCLUSIONS

The results suggest that bone turnover in inflammatory bowel disease is characterized by low bone formation in the presence of normal levels of calcium-regulating hormones.

Authors+Show Affiliations

Service d'Hepato-gastroentérologie, Hôpital Cochin, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7835582

Citation

Abitbol, V, et al. "Metabolic Bone Assessment in Patients With Inflammatory Bowel Disease." Gastroenterology, vol. 108, no. 2, 1995, pp. 417-22.
Abitbol V, Roux C, Chaussade S, et al. Metabolic bone assessment in patients with inflammatory bowel disease. Gastroenterology. 1995;108(2):417-22.
Abitbol, V., Roux, C., Chaussade, S., Guillemant, S., Kolta, S., Dougados, M., ... Amor, B. (1995). Metabolic bone assessment in patients with inflammatory bowel disease. Gastroenterology, 108(2), pp. 417-22.
Abitbol V, et al. Metabolic Bone Assessment in Patients With Inflammatory Bowel Disease. Gastroenterology. 1995;108(2):417-22. PubMed PMID: 7835582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic bone assessment in patients with inflammatory bowel disease. AU - Abitbol,V, AU - Roux,C, AU - Chaussade,S, AU - Guillemant,S, AU - Kolta,S, AU - Dougados,M, AU - Couturier,D, AU - Amor,B, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 417 EP - 22 JF - Gastroenterology JO - Gastroenterology VL - 108 IS - 2 N2 - BACKGROUND/AIMS: Patients with inflammatory bowel disease are at risk for osteopenia. To study the metabolic bone status of these patients, a cross-sectional study was conducted. METHODS: Eighty-four patients (49 women, 35 men) with inflammatory bowel disease, 34 of whom had Crohn's disease and 50 ulcerative colitis (including 18 with prior coloproctectomy and ileoanal anastomosis), underwent clinical, dietary, and spine radiological assessments. Bone metabolism was assessed by measuring serum levels of calcium, phosphate, parathyroid hormone (1-84), 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, and osteocalcin. Lumbar and femoral neck bone mineral densities were measured by dual energy X-ray absorptiometry. RESULTS: Serum osteocalcin level was decreased in 29 patients (34%), 12 of whom had never undergone steroid therapy. The other biochemical markers of bone metabolism were in the normal range. Thirty-six patients (43%) had osteopenia, and 6 patients (7%) had vertebral crush fractures. Osteopenia was observed in 27 patients (52%) and 9 patients (28%) with and without corticosteroid therapy, respectively. No patient had clinical or biological signs of osteomalacia. Analysis of bone density (lumbar Z score) by a multiple regression analysis showed a statistically significant correlation with age, cumulative corticosteroid doses, sedimentation rate, and osteocalcin level (R2 = 0.76; P = 0.05). CONCLUSIONS: The results suggest that bone turnover in inflammatory bowel disease is characterized by low bone formation in the presence of normal levels of calcium-regulating hormones. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/7835582/Metabolic_bone_assessment_in_patients_with_inflammatory_bowel_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0016-5085(95)90068-3 DB - PRIME DP - Unbound Medicine ER -