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cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12.
Genomics. 1994 Sep 15; 23(2):500-3.G

Abstract

Lactate and pyruvate are transported across cell membranes by monocarboxylate transporters (MCTs). Here, we use the recently cloned cDNA for hamster MCT1 to isolate cDNA and genomic clones for human MCT1. Comparison of the human and hamster amino acid sequences revealed that the proteins are 86% identical. The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13.2-p12 by PCR analysis of panels of human x rodent cell hybrid lines and by fluorescence chromosomal in situ hybridization.

Authors+Show Affiliations

Garcia CK
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235-9046.
Li X
No affiliation info available
Luna J
No affiliation info available
Francke U
No affiliation info available

MeSH

Amino Acid SequenceAnimalsBase SequenceCarrier ProteinsChromosome MappingChromosomes, Human, Pair 1Cloning, MolecularCricetinaeDNA PrimersDNA, ComplementaryHumansHybrid CellsIn Situ Hybridization, FluorescenceMolecular Sequence DataMonocarboxylic Acid TransportersSequence Homology, Amino AcidSpecies Specificity

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7835905

Citation

Garcia, C K., et al. "CDNA Cloning of the Human Monocarboxylate Transporter 1 and Chromosomal Localization of the SLC16A1 Locus to 1p13.2-p12." Genomics, vol. 23, no. 2, 1994, pp. 500-3.
Garcia CK, Li X, Luna J, et al. CDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994;23(2):500-3.
Garcia, C. K., Li, X., Luna, J., & Francke, U. (1994). CDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics, 23(2), 500-3.
Garcia CK, et al. CDNA Cloning of the Human Monocarboxylate Transporter 1 and Chromosomal Localization of the SLC16A1 Locus to 1p13.2-p12. Genomics. 1994 Sep 15;23(2):500-3. PubMed PMID: 7835905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. AU - Garcia,C K, AU - Li,X, AU - Luna,J, AU - Francke,U, PY - 1994/9/15/pubmed PY - 1994/9/15/medline PY - 1994/9/15/entrez SP - 500 EP - 3 JF - Genomics JO - Genomics VL - 23 IS - 2 N2 - Lactate and pyruvate are transported across cell membranes by monocarboxylate transporters (MCTs). Here, we use the recently cloned cDNA for hamster MCT1 to isolate cDNA and genomic clones for human MCT1. Comparison of the human and hamster amino acid sequences revealed that the proteins are 86% identical. The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13.2-p12 by PCR analysis of panels of human x rodent cell hybrid lines and by fluorescence chromosomal in situ hybridization. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/7835905/cDNA_cloning_of_the_human_monocarboxylate_transporter_1_and_chromosomal_localization_of_the_SLC16A1_locus_to_1p13_2_p12_ DB - PRIME DP - Unbound Medicine ER -