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Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing molecules and their functional properties in eosinophils from patients with the idiopathic hypereosinophilic syndrome.
Immunology. 1994 Oct; 83(2):313-8.I

Abstract

As the carbohydrate lacto-N-fucopentaose III (CD15 antigen or X-determinant) and its sialylated derivative sialyl-Lewis X are involved in the adhesion of cells rolling along the surface of endothelial cells, experiments were done to study the presence of these molecules on human eosinophils from patients with the idiopathic hypereosinophilic syndrome. Normal-density eosinophils from some patients showed higher levels of expression for lacto-N-fucopentaose III than light-density eosinophils. In contrast, sialyl-Lewis X was highly expressed by light-density eosinophils. Activation of normal-density eosinophils with calcium ionophore A23187 resulted in increased expression of these molecules for a short time. Monoclonal antibodies to these carbohydrates stimulated eosinophils to secrete eosinophil cationic protein, but not eosinophil peroxidase, and acted as costimulatory signals for C3b-induced degranulation of eosinophil cationic protein. It was suggested that CD15 and sialyl-Lewis X might contribute to eosinophil-mediated tissue injury in patients with the idiopathic hypereosinophilic syndrome.

Authors+Show Affiliations

Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7835953

Citation

Satoh, T, et al. "Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing Molecules and Their Functional Properties in Eosinophils From Patients With the Idiopathic Hypereosinophilic Syndrome." Immunology, vol. 83, no. 2, 1994, pp. 313-8.
Satoh T, Knowles A, Li MS, et al. Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing molecules and their functional properties in eosinophils from patients with the idiopathic hypereosinophilic syndrome. Immunology. 1994;83(2):313-8.
Satoh, T., Knowles, A., Li, M. S., Sun, L., Tooze, J. A., Zabucchi, G., & Spry, C. J. (1994). Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing molecules and their functional properties in eosinophils from patients with the idiopathic hypereosinophilic syndrome. Immunology, 83(2), 313-8.
Satoh T, et al. Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing Molecules and Their Functional Properties in Eosinophils From Patients With the Idiopathic Hypereosinophilic Syndrome. Immunology. 1994;83(2):313-8. PubMed PMID: 7835953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing molecules and their functional properties in eosinophils from patients with the idiopathic hypereosinophilic syndrome. AU - Satoh,T, AU - Knowles,A, AU - Li,M S, AU - Sun,L, AU - Tooze,J A, AU - Zabucchi,G, AU - Spry,C J, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 313 EP - 8 JF - Immunology JO - Immunology VL - 83 IS - 2 N2 - As the carbohydrate lacto-N-fucopentaose III (CD15 antigen or X-determinant) and its sialylated derivative sialyl-Lewis X are involved in the adhesion of cells rolling along the surface of endothelial cells, experiments were done to study the presence of these molecules on human eosinophils from patients with the idiopathic hypereosinophilic syndrome. Normal-density eosinophils from some patients showed higher levels of expression for lacto-N-fucopentaose III than light-density eosinophils. In contrast, sialyl-Lewis X was highly expressed by light-density eosinophils. Activation of normal-density eosinophils with calcium ionophore A23187 resulted in increased expression of these molecules for a short time. Monoclonal antibodies to these carbohydrates stimulated eosinophils to secrete eosinophil cationic protein, but not eosinophil peroxidase, and acted as costimulatory signals for C3b-induced degranulation of eosinophil cationic protein. It was suggested that CD15 and sialyl-Lewis X might contribute to eosinophil-mediated tissue injury in patients with the idiopathic hypereosinophilic syndrome. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/7835953/Expression_of_lacto_N_fucopentaose_III__CD15___and_sialyl_Lewis_X_bearing_molecules_and_their_functional_properties_in_eosinophils_from_patients_with_the_idiopathic_hypereosinophilic_syndrome_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7835953/ DB - PRIME DP - Unbound Medicine ER -