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Effects of glucocorticoids and endurance training on cytochrome oxidase expression in skeletal muscle.
J Appl Physiol (1985). 1994 Oct; 77(4):1685-90.JA

Abstract

This investigation was undertaken to evaluate whether the mitochondrial disfunction associated with glucocorticoid treatment is expressed at the level of cytochrome-c oxidase (COX) and whether endurance training attenuates this response. Adult female rats were administered cortisol acetate (100 mg/kg body wt) or an equal volume of the vehicle solution for 11 days. Endurance training was performed by treadmill running up to 28 m/min (with intervals at 50 m/min for 2 min every 15 min), for 90 min/day, 6 days/wk, for 8-10 wk. During hormone treatments, the training animals ran every day. Exercise prevented 43-55% of the hormone-induced atrophy in various fast-twitch muscles or muscle groups. Cortisol acetate treatment produced no significant effects on COX enzyme activities or subunit mRNA content in deep red or superficial white quadriceps or mixed plantaris muscles. The levels of COX were increased as a result of training by 70-110% in plantaris and red quadriceps muscles, but no changes were seen in white quadriceps muscles. Both nuclear-encoded (COX IV) and mitochondrial-encoded (COX III) mRNAs were increased approximately twofold by the exercise program in these same muscles. These data indicate that the impaired mitochondrial functioning associated with glucocorticoids is not observed at the COX step of electron transport. The prolonged endurance-training regimen appears to induce relatively parallel increases in COX enzyme activity and mRNA expression with coordinate changes in nuclear and mitochondrial mRNAs.

Authors+Show Affiliations

School of Kinesiology, University of Illinois at Chicago 60608-1516.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7836187

Citation

Marone, J R., et al. "Effects of Glucocorticoids and Endurance Training On Cytochrome Oxidase Expression in Skeletal Muscle." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 77, no. 4, 1994, pp. 1685-90.
Marone JR, Falduto MT, Essig DA, et al. Effects of glucocorticoids and endurance training on cytochrome oxidase expression in skeletal muscle. J Appl Physiol (1985). 1994;77(4):1685-90.
Marone, J. R., Falduto, M. T., Essig, D. A., & Hickson, R. C. (1994). Effects of glucocorticoids and endurance training on cytochrome oxidase expression in skeletal muscle. Journal of Applied Physiology (Bethesda, Md. : 1985), 77(4), 1685-90.
Marone JR, et al. Effects of Glucocorticoids and Endurance Training On Cytochrome Oxidase Expression in Skeletal Muscle. J Appl Physiol (1985). 1994;77(4):1685-90. PubMed PMID: 7836187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of glucocorticoids and endurance training on cytochrome oxidase expression in skeletal muscle. AU - Marone,J R, AU - Falduto,M T, AU - Essig,D A, AU - Hickson,R C, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1685 EP - 90 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 77 IS - 4 N2 - This investigation was undertaken to evaluate whether the mitochondrial disfunction associated with glucocorticoid treatment is expressed at the level of cytochrome-c oxidase (COX) and whether endurance training attenuates this response. Adult female rats were administered cortisol acetate (100 mg/kg body wt) or an equal volume of the vehicle solution for 11 days. Endurance training was performed by treadmill running up to 28 m/min (with intervals at 50 m/min for 2 min every 15 min), for 90 min/day, 6 days/wk, for 8-10 wk. During hormone treatments, the training animals ran every day. Exercise prevented 43-55% of the hormone-induced atrophy in various fast-twitch muscles or muscle groups. Cortisol acetate treatment produced no significant effects on COX enzyme activities or subunit mRNA content in deep red or superficial white quadriceps or mixed plantaris muscles. The levels of COX were increased as a result of training by 70-110% in plantaris and red quadriceps muscles, but no changes were seen in white quadriceps muscles. Both nuclear-encoded (COX IV) and mitochondrial-encoded (COX III) mRNAs were increased approximately twofold by the exercise program in these same muscles. These data indicate that the impaired mitochondrial functioning associated with glucocorticoids is not observed at the COX step of electron transport. The prolonged endurance-training regimen appears to induce relatively parallel increases in COX enzyme activity and mRNA expression with coordinate changes in nuclear and mitochondrial mRNAs. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/7836187/Effects_of_glucocorticoids_and_endurance_training_on_cytochrome_oxidase_expression_in_skeletal_muscle_ L2 - https://journals.physiology.org/doi/10.1152/jappl.1994.77.4.1685?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -