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Hyperinsulinaemia and blood pressure in a general Japanese population: the Hisayama Study.
J Hypertens. 1994 Oct; 12(10):1191-7.JH

Abstract

OBJECTIVES

To study the relationship between serum insulin and blood pressure, as well as the prevalence of hypertension according to the insulin level in a general Japanese population.

DESIGN

In 1988 a cross-sectional community survey was conducted among Hisayama residents aged 40-79 years.

METHODS

A total of 1073 males and 1407 females (72.5 and 80.5% of the total population, respectively) underwent comprehensive investigation, including a 75-g oral glucose-tolerance test. Fasting and 2-h serum insulin levels were measured by radioimmunoassay.

RESULTS

The sum of the fasting and 2-h postloading insulin levels was significantly correlated with the systolic blood pressure (SBP; r = 0.18 and 0.26 for males and females, respectively) and the diastolic blood pressure (DBP; r = 0.24 and 0.19, respectively) in the subjects not receiving antihypertensive drugs. In multiple regression analysis the correlation with blood pressure remained significant in both sexes even after controlling for age, body mass index, alcohol intake, smoking, a family history of hypertension, serum total cholesterol and fasting plasma glucose. The age- and sex-adjusted prevalence of hypertension (SBP > or = 160 mmHg or DBP > or = 95 mmHg, or both, or receiving drug treatment) increased significantly with an increase in the sum of fasting and 2-h postload insulin levels in both the non-obese subjects (body mass index < 25 kg/m2) and the obese subjects (body mass index > or = 25 kg/m2). Multiple logistic regression showed that the sum of fasting and 2-h postload insulin levels was a significant factor with an independent relationship to hypertension, even after taking the other risk factors into account.

CONCLUSION

The present study suggests that hyperinsulinaemia is related to hypertension in a general Japanese population.

Authors+Show Affiliations

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7836736

Citation

Ohmori, S, et al. "Hyperinsulinaemia and Blood Pressure in a General Japanese Population: the Hisayama Study." Journal of Hypertension, vol. 12, no. 10, 1994, pp. 1191-7.
Ohmori S, Kiyohara Y, Kato I, et al. Hyperinsulinaemia and blood pressure in a general Japanese population: the Hisayama Study. J Hypertens. 1994;12(10):1191-7.
Ohmori, S., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Nomiyama, K., Yoshitake, T., Ueda, K., & Fujishima, M. (1994). Hyperinsulinaemia and blood pressure in a general Japanese population: the Hisayama Study. Journal of Hypertension, 12(10), 1191-7.
Ohmori S, et al. Hyperinsulinaemia and Blood Pressure in a General Japanese Population: the Hisayama Study. J Hypertens. 1994;12(10):1191-7. PubMed PMID: 7836736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperinsulinaemia and blood pressure in a general Japanese population: the Hisayama Study. AU - Ohmori,S, AU - Kiyohara,Y, AU - Kato,I, AU - Ohmura,T, AU - Iwamoto,H, AU - Nakayama,K, AU - Nomiyama,K, AU - Yoshitake,T, AU - Ueda,K, AU - Fujishima,M, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1191 EP - 7 JF - Journal of hypertension JO - J Hypertens VL - 12 IS - 10 N2 - OBJECTIVES: To study the relationship between serum insulin and blood pressure, as well as the prevalence of hypertension according to the insulin level in a general Japanese population. DESIGN: In 1988 a cross-sectional community survey was conducted among Hisayama residents aged 40-79 years. METHODS: A total of 1073 males and 1407 females (72.5 and 80.5% of the total population, respectively) underwent comprehensive investigation, including a 75-g oral glucose-tolerance test. Fasting and 2-h serum insulin levels were measured by radioimmunoassay. RESULTS: The sum of the fasting and 2-h postloading insulin levels was significantly correlated with the systolic blood pressure (SBP; r = 0.18 and 0.26 for males and females, respectively) and the diastolic blood pressure (DBP; r = 0.24 and 0.19, respectively) in the subjects not receiving antihypertensive drugs. In multiple regression analysis the correlation with blood pressure remained significant in both sexes even after controlling for age, body mass index, alcohol intake, smoking, a family history of hypertension, serum total cholesterol and fasting plasma glucose. The age- and sex-adjusted prevalence of hypertension (SBP > or = 160 mmHg or DBP > or = 95 mmHg, or both, or receiving drug treatment) increased significantly with an increase in the sum of fasting and 2-h postload insulin levels in both the non-obese subjects (body mass index < 25 kg/m2) and the obese subjects (body mass index > or = 25 kg/m2). Multiple logistic regression showed that the sum of fasting and 2-h postload insulin levels was a significant factor with an independent relationship to hypertension, even after taking the other risk factors into account. CONCLUSION: The present study suggests that hyperinsulinaemia is related to hypertension in a general Japanese population. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/7836736/Hyperinsulinaemia_and_blood_pressure_in_a_general_Japanese_population:_the_Hisayama_Study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=7836736.ui DB - PRIME DP - Unbound Medicine ER -