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Effect of obesity on the clinical and hormonal characteristics of the polycystic ovary syndrome.
J Reprod Med. 1994 Oct; 39(10):805-8.JR

Abstract

The polycystic ovary (PCO) syndrome is frequently associated with obesity. That subset of women reportedly shows a much higher incidence of hirsutism and menstrual irregularities than do nonobese women with PCO syndrome. We evaluated the clinical features and hormonal profiles of 56 women with PCO syndrome and correlated them with the presence or absence of obesity. Thirty-eight (67.8%) of these women were obese (body mass index > or = 25 kg/m2). While presenting with the classic manifestations of PCO, they did not differ significantly from the manifestations of nonobese women with PCO syndrome. Although obese women with PCO had a lower incidence of oligomenorrhea as compared to nonobese women with PCO (57.9% vs. 83.3%, respectively) and amenorrhea was more frequent in the former group (42.1% vs. 16.6%, respectively), these findings are not statistically significant. The incidences of hirsutism and anovulatory infertility in the obese group as compared to the nonobese group were 81.6% vs. 77.8% and 28.9% vs. 27.8%, respectively (not statistically significantly different). The mean (+/- SE) serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH ratios, prolactin and testosterone were not statistically significantly different among the two groups. The present study found that obesity is common in PCO syndrome but that there are no significant differences in the clinical and hormonal characteristics of obese and nonobese women with it. Further studies are warranted to clarify the impact of obesity on clinical, metabolic and hormonal changes in PCO syndrome.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Louisiana State University School of Medicine, Shreveport 71130.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7837128

Citation

Singh, K B., et al. "Effect of Obesity On the Clinical and Hormonal Characteristics of the Polycystic Ovary Syndrome." The Journal of Reproductive Medicine, vol. 39, no. 10, 1994, pp. 805-8.
Singh KB, Mahajan DK, Wortsman J. Effect of obesity on the clinical and hormonal characteristics of the polycystic ovary syndrome. J Reprod Med. 1994;39(10):805-8.
Singh, K. B., Mahajan, D. K., & Wortsman, J. (1994). Effect of obesity on the clinical and hormonal characteristics of the polycystic ovary syndrome. The Journal of Reproductive Medicine, 39(10), 805-8.
Singh KB, Mahajan DK, Wortsman J. Effect of Obesity On the Clinical and Hormonal Characteristics of the Polycystic Ovary Syndrome. J Reprod Med. 1994;39(10):805-8. PubMed PMID: 7837128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of obesity on the clinical and hormonal characteristics of the polycystic ovary syndrome. AU - Singh,K B, AU - Mahajan,D K, AU - Wortsman,J, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 805 EP - 8 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 39 IS - 10 N2 - The polycystic ovary (PCO) syndrome is frequently associated with obesity. That subset of women reportedly shows a much higher incidence of hirsutism and menstrual irregularities than do nonobese women with PCO syndrome. We evaluated the clinical features and hormonal profiles of 56 women with PCO syndrome and correlated them with the presence or absence of obesity. Thirty-eight (67.8%) of these women were obese (body mass index > or = 25 kg/m2). While presenting with the classic manifestations of PCO, they did not differ significantly from the manifestations of nonobese women with PCO syndrome. Although obese women with PCO had a lower incidence of oligomenorrhea as compared to nonobese women with PCO (57.9% vs. 83.3%, respectively) and amenorrhea was more frequent in the former group (42.1% vs. 16.6%, respectively), these findings are not statistically significant. The incidences of hirsutism and anovulatory infertility in the obese group as compared to the nonobese group were 81.6% vs. 77.8% and 28.9% vs. 27.8%, respectively (not statistically significantly different). The mean (+/- SE) serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH ratios, prolactin and testosterone were not statistically significantly different among the two groups. The present study found that obesity is common in PCO syndrome but that there are no significant differences in the clinical and hormonal characteristics of obese and nonobese women with it. Further studies are warranted to clarify the impact of obesity on clinical, metabolic and hormonal changes in PCO syndrome. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/7837128/Effect_of_obesity_on_the_clinical_and_hormonal_characteristics_of_the_polycystic_ovary_syndrome_ L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -