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Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial.
Vaccine 1994; 12(13):1185-9V

Abstract

The objective of this study was to determine the immune response to influenza vaccination in elderly people, using a randomized, double-blind, placebo-controlled trial. Venous blood was taken from 1838 people aged 60 years and older, prior to injection with the influenza vaccine or a placebo. A second blood sample was taken three weeks later. The antibody reaction was measured by comparing the geometric mean titre and the percentage of participants who had a protective antibody titre before and after vaccination and for all sera of each strain. A protective antibody titre was found in 43-68% of those who had received the vaccine, depending on the strain investigated. Patients potentially at risk showed a response similar to the other participants. We conclude that influenza vaccination in elderly people provides a reasonable to good immune response. Research is needed on whether a good immune response decreases the incidence of influenza.

Authors+Show Affiliations

Department of General Practice, University of Limburg, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7839722

Citation

Govaert, T M., et al. "Immune Response to Influenza Vaccination of Elderly People. a Randomized Double-blind Placebo-controlled Trial." Vaccine, vol. 12, no. 13, 1994, pp. 1185-9.
Govaert TM, Sprenger MJ, Dinant GJ, et al. Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial. Vaccine. 1994;12(13):1185-9.
Govaert, T. M., Sprenger, M. J., Dinant, G. J., Aretz, K., Masurel, N., & Knottnerus, J. A. (1994). Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial. Vaccine, 12(13), pp. 1185-9.
Govaert TM, et al. Immune Response to Influenza Vaccination of Elderly People. a Randomized Double-blind Placebo-controlled Trial. Vaccine. 1994;12(13):1185-9. PubMed PMID: 7839722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial. AU - Govaert,T M, AU - Sprenger,M J, AU - Dinant,G J, AU - Aretz,K, AU - Masurel,N, AU - Knottnerus,J A, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 1185 EP - 9 JF - Vaccine JO - Vaccine VL - 12 IS - 13 N2 - The objective of this study was to determine the immune response to influenza vaccination in elderly people, using a randomized, double-blind, placebo-controlled trial. Venous blood was taken from 1838 people aged 60 years and older, prior to injection with the influenza vaccine or a placebo. A second blood sample was taken three weeks later. The antibody reaction was measured by comparing the geometric mean titre and the percentage of participants who had a protective antibody titre before and after vaccination and for all sera of each strain. A protective antibody titre was found in 43-68% of those who had received the vaccine, depending on the strain investigated. Patients potentially at risk showed a response similar to the other participants. We conclude that influenza vaccination in elderly people provides a reasonable to good immune response. Research is needed on whether a good immune response decreases the incidence of influenza. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/7839722/Immune_response_to_influenza_vaccination_of_elderly_people__A_randomized_double_blind_placebo_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0264-410X(94)90241-0 DB - PRIME DP - Unbound Medicine ER -