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Common neurologic complications of HIV-1 infection and AIDS.
Am Fam Physician 1995; 51(2):387-98AF

Abstract

Complications of human immunodeficiency virus type 1 infection and acquired immunodeficiency syndrome may involve any level of the central or peripheral nervous system. Acute encephalitis, aseptic meningitis and acute demyelinating polyneuropathy may occur early in the course of HIV infection, while dementia, central nervous system-related cancer, opportunistic infections and autonomic neuropathy typically present later. Headache and mental status changes are common early manifestations of central nervous system involvement. Most severe headaches are related to an identifiable cause, including a mass lesion, opportunistic cerebral infection and medication side effect. Memory deficits, concentration difficulties and abnormalities on mental status testing may represent early AIDS dementia complex (HIV encephalopathy), the most common neurologic complication. In patients with AIDs, the differential diagnosis of cerebral mass lesions on computed tomography or magnetic resonance imaging includes cerebral toxoplasmosis, tuberculous or fungal abscess, focal viral encephalitis, metastatic resonance imaging includes cerebral toxoplasmosis, tuberculous or fungal abscess, focal viral encephalitis, metastatic Kaposi's sarcoma and primary CNS lymphoma. Peripheral neuromuscular disease, including distal symmetric polyneuropathy, autonomic neuropathy, and HIV and chronic zidovudine myopathy, affects 15 to 40 percent of all persons with HIV infection or AIDS.

Authors+Show Affiliations

Ohio State University Hospitals, Columbus.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

7840035

Citation

Newton, H B.. "Common Neurologic Complications of HIV-1 Infection and AIDS." American Family Physician, vol. 51, no. 2, 1995, pp. 387-98.
Newton HB. Common neurologic complications of HIV-1 infection and AIDS. Am Fam Physician. 1995;51(2):387-98.
Newton, H. B. (1995). Common neurologic complications of HIV-1 infection and AIDS. American Family Physician, 51(2), pp. 387-98.
Newton HB. Common Neurologic Complications of HIV-1 Infection and AIDS. Am Fam Physician. 1995 Feb 1;51(2):387-98. PubMed PMID: 7840035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Common neurologic complications of HIV-1 infection and AIDS. A1 - Newton,H B, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 387 EP - 98 JF - American family physician JO - Am Fam Physician VL - 51 IS - 2 N2 - Complications of human immunodeficiency virus type 1 infection and acquired immunodeficiency syndrome may involve any level of the central or peripheral nervous system. Acute encephalitis, aseptic meningitis and acute demyelinating polyneuropathy may occur early in the course of HIV infection, while dementia, central nervous system-related cancer, opportunistic infections and autonomic neuropathy typically present later. Headache and mental status changes are common early manifestations of central nervous system involvement. Most severe headaches are related to an identifiable cause, including a mass lesion, opportunistic cerebral infection and medication side effect. Memory deficits, concentration difficulties and abnormalities on mental status testing may represent early AIDS dementia complex (HIV encephalopathy), the most common neurologic complication. In patients with AIDs, the differential diagnosis of cerebral mass lesions on computed tomography or magnetic resonance imaging includes cerebral toxoplasmosis, tuberculous or fungal abscess, focal viral encephalitis, metastatic resonance imaging includes cerebral toxoplasmosis, tuberculous or fungal abscess, focal viral encephalitis, metastatic Kaposi's sarcoma and primary CNS lymphoma. Peripheral neuromuscular disease, including distal symmetric polyneuropathy, autonomic neuropathy, and HIV and chronic zidovudine myopathy, affects 15 to 40 percent of all persons with HIV infection or AIDS. SN - 0002-838X UR - https://www.unboundmedicine.com/medline/citation/7840035/Common_neurologic_complications_of_HIV_1_infection_and_AIDS_ L2 - http://www.diseaseinfosearch.org/result/279 DB - PRIME DP - Unbound Medicine ER -