Tags

Type your tag names separated by a space and hit enter

Autonomic responses of the insular cortex in hypertensive and normotensive rats.
Am J Physiol. 1995 Jan; 268(1 Pt 2):R214-22.AJ

Abstract

Lesion and focal cerebral ischemia of the insular cortex (IC) results in elevated renal sympathetic nerve activity (RSNA) and arterial pressure (AP) in the Wistar rat, while the opposite effect is observed in the spontaneously hypertensive rat (SHR). Acute changes in AP, heart rate (HR) and RSNA were measured in propofol-anesthetized and conscious SHR (n = 17) and Wistar rats (n = 17) during pressure injection of D,L-homocysteic acid (DLH; 100 mM) and lidocaine (LID; 20 mg/ml) into the IC. DLH injections (200 nl) into the IC of anesthetized Wistar rats resulted in a significant increase in MAP (mean change = +27 +/- 7 mmHg; P < 0.05) and a significant decrease in HR (-22 +/- 9 beats/min) and RSNA (-11 +/- 4 microV.s). Neither DLH nor LID injections into the IC of anesthetized SHR affected MAP or RNA. DLH and LID injections (500 nl) into the IC of conscious Wistar rats both resulted in a significant increase in MAP (+26 +/- 5 mmHg; 11 +/- 4 mmHg, respectively). Neither DLH nor LID injections had any cardiovascular effects in the conscious SHR. It therefore appears that the IC of conscious Wistar rats has a tonic inhibitory output, while neural excitation is capable of eliciting pressor responses. Conversely, the IC of SHR appears to exert no tonic influence on MAP.

Authors+Show Affiliations

Department of Stroke and Aging, John P. Robarts Research Institute, London, Ontario N6A 5K8, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7840324

Citation

Butcher, K S., and D F. Cechetto. "Autonomic Responses of the Insular Cortex in Hypertensive and Normotensive Rats." The American Journal of Physiology, vol. 268, no. 1 Pt 2, 1995, pp. R214-22.
Butcher KS, Cechetto DF. Autonomic responses of the insular cortex in hypertensive and normotensive rats. Am J Physiol. 1995;268(1 Pt 2):R214-22.
Butcher, K. S., & Cechetto, D. F. (1995). Autonomic responses of the insular cortex in hypertensive and normotensive rats. The American Journal of Physiology, 268(1 Pt 2), R214-22.
Butcher KS, Cechetto DF. Autonomic Responses of the Insular Cortex in Hypertensive and Normotensive Rats. Am J Physiol. 1995;268(1 Pt 2):R214-22. PubMed PMID: 7840324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic responses of the insular cortex in hypertensive and normotensive rats. AU - Butcher,K S, AU - Cechetto,D F, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - R214 EP - 22 JF - The American journal of physiology JO - Am. J. Physiol. VL - 268 IS - 1 Pt 2 N2 - Lesion and focal cerebral ischemia of the insular cortex (IC) results in elevated renal sympathetic nerve activity (RSNA) and arterial pressure (AP) in the Wistar rat, while the opposite effect is observed in the spontaneously hypertensive rat (SHR). Acute changes in AP, heart rate (HR) and RSNA were measured in propofol-anesthetized and conscious SHR (n = 17) and Wistar rats (n = 17) during pressure injection of D,L-homocysteic acid (DLH; 100 mM) and lidocaine (LID; 20 mg/ml) into the IC. DLH injections (200 nl) into the IC of anesthetized Wistar rats resulted in a significant increase in MAP (mean change = +27 +/- 7 mmHg; P < 0.05) and a significant decrease in HR (-22 +/- 9 beats/min) and RSNA (-11 +/- 4 microV.s). Neither DLH nor LID injections into the IC of anesthetized SHR affected MAP or RNA. DLH and LID injections (500 nl) into the IC of conscious Wistar rats both resulted in a significant increase in MAP (+26 +/- 5 mmHg; 11 +/- 4 mmHg, respectively). Neither DLH nor LID injections had any cardiovascular effects in the conscious SHR. It therefore appears that the IC of conscious Wistar rats has a tonic inhibitory output, while neural excitation is capable of eliciting pressor responses. Conversely, the IC of SHR appears to exert no tonic influence on MAP. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/7840324/Autonomic_responses_of_the_insular_cortex_in_hypertensive_and_normotensive_rats_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpregu.1995.268.1.R214?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -