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Anorectal manometry in the assessment of anorectal function in Parkinson's disease: a comparison with chronic idiopathic constipation.
Mov Disord. 1994 Nov; 9(6):655-63.MD

Abstract

We investigated the role of anorectal manometry in evaluating constipation and anorectal function in 15 patients with Parkinson's disease (PD) and compared results with those of 9 patients with idiopathic constipation (IC) and 8 control (C) subjects. Anal sphincter pressures on voluntary squeeze were lower in the PD patients. Sustained squeeze pressures (mm Hg C versus IC versus PD: 46.8 +/- 5.2 versus 31.2 +/- 3.6 versus 26.6 +/- 3.9; p < 0.05 PD versus C), squeeze duration (seconds: 53.6 +/- 2.5 versus 48.5 +/- 4.1 versus 33.6 +/- 9; p < 0.05 PD versus C) and squeeze index (area under the squeeze curve: 44.0 +/- 2.9 versus 34.5 +/- 3.3 versus 21.4 +/- 2.9; p < 0.001 PD versus C) were significantly lower in the PD group in comparison to the control group. In contrast, none of the parameters of anorectal manometry differed between controls and patients with idiopathic constipation. Some Parkinson's disease patients demonstrated an abnormal, hypercontractile response on testing of the rectoanal inhibitory reflex. Anal sphincter length, basal sphincter pressures, maximal squeeze pressures, extent of relaxation on rectoanal inhibitory reflex and threshold volume for rectal sensation were similar in the three groups. We conclude that an impaired squeeze response is a specific feature of anorectal function in Parkinson's disease. This may indicate direct involvement of the pelvic floor musculature by the parkinsonian disease process.

Authors+Show Affiliations

Section of Digestive Diseases, University of Nebraska Medical Center, Omaha 68198-2000.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7845407

Citation

Ashraf, W, et al. "Anorectal Manometry in the Assessment of Anorectal Function in Parkinson's Disease: a Comparison With Chronic Idiopathic Constipation." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 9, no. 6, 1994, pp. 655-63.
Ashraf W, Pfeiffer RF, Quigley EM. Anorectal manometry in the assessment of anorectal function in Parkinson's disease: a comparison with chronic idiopathic constipation. Mov Disord. 1994;9(6):655-63.
Ashraf, W., Pfeiffer, R. F., & Quigley, E. M. (1994). Anorectal manometry in the assessment of anorectal function in Parkinson's disease: a comparison with chronic idiopathic constipation. Movement Disorders : Official Journal of the Movement Disorder Society, 9(6), 655-63.
Ashraf W, Pfeiffer RF, Quigley EM. Anorectal Manometry in the Assessment of Anorectal Function in Parkinson's Disease: a Comparison With Chronic Idiopathic Constipation. Mov Disord. 1994;9(6):655-63. PubMed PMID: 7845407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anorectal manometry in the assessment of anorectal function in Parkinson's disease: a comparison with chronic idiopathic constipation. AU - Ashraf,W, AU - Pfeiffer,R F, AU - Quigley,E M, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 655 EP - 63 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 9 IS - 6 N2 - We investigated the role of anorectal manometry in evaluating constipation and anorectal function in 15 patients with Parkinson's disease (PD) and compared results with those of 9 patients with idiopathic constipation (IC) and 8 control (C) subjects. Anal sphincter pressures on voluntary squeeze were lower in the PD patients. Sustained squeeze pressures (mm Hg C versus IC versus PD: 46.8 +/- 5.2 versus 31.2 +/- 3.6 versus 26.6 +/- 3.9; p < 0.05 PD versus C), squeeze duration (seconds: 53.6 +/- 2.5 versus 48.5 +/- 4.1 versus 33.6 +/- 9; p < 0.05 PD versus C) and squeeze index (area under the squeeze curve: 44.0 +/- 2.9 versus 34.5 +/- 3.3 versus 21.4 +/- 2.9; p < 0.001 PD versus C) were significantly lower in the PD group in comparison to the control group. In contrast, none of the parameters of anorectal manometry differed between controls and patients with idiopathic constipation. Some Parkinson's disease patients demonstrated an abnormal, hypercontractile response on testing of the rectoanal inhibitory reflex. Anal sphincter length, basal sphincter pressures, maximal squeeze pressures, extent of relaxation on rectoanal inhibitory reflex and threshold volume for rectal sensation were similar in the three groups. We conclude that an impaired squeeze response is a specific feature of anorectal function in Parkinson's disease. This may indicate direct involvement of the pelvic floor musculature by the parkinsonian disease process. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/7845407/Anorectal_manometry_in_the_assessment_of_anorectal_function_in_Parkinson's_disease:_a_comparison_with_chronic_idiopathic_constipation_ L2 - https://doi.org/10.1002/mds.870090612 DB - PRIME DP - Unbound Medicine ER -