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[Insulin resistance and cardiovascular complications].
Wien Klin Wochenschr 1994; 106(24):758-62WK

Abstract

Several epidemiologic and clinical studies over the past years have shown that insulin resistance and hyperinsulinemia are related to dyslipidemia, hypertension, android obesity and non-insulin-dependent diabetes mellitus (NIDDM). The insulin-resistance syndrome is thus closely associated with a cluster of potent cardiovascular risk factors, thereby explaining the 3-4 times higher incidence of cardiovascular disease in NIDDM. Recent observations point to the fact that insulin resistance is genetically determined and can be diagnosed a long time before the clinical manifestation of diabetes mellitus in the prediabetic stage (stage of hyperinsulinemia, hypertension and hyperlipidemia). Hence, it is not surprising that many NIDDM subjects suffer from cardiovascular complications already at the time diabetes is diagnosed. The pathogenetic mechanism of insulin resistance/hyperinsulinemia as cardiovascular risk factor is considered to be a direct atherogenic action of insulin on vessel wall cells and an indirect effect on upper body obesity, blood pressure, lipids and hemostasis.

Authors+Show Affiliations

II. Medizinische Abteilung, Zentralkrankenhaus Bremen-Nord, Bundesrepublik Deutschland.

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

7846894

Citation

Janka, H U.. "[Insulin Resistance and Cardiovascular Complications]." Wiener Klinische Wochenschrift, vol. 106, no. 24, 1994, pp. 758-62.
Janka HU. [Insulin resistance and cardiovascular complications]. Wien Klin Wochenschr. 1994;106(24):758-62.
Janka, H. U. (1994). [Insulin resistance and cardiovascular complications]. Wiener Klinische Wochenschrift, 106(24), pp. 758-62.
Janka HU. [Insulin Resistance and Cardiovascular Complications]. Wien Klin Wochenschr. 1994;106(24):758-62. PubMed PMID: 7846894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Insulin resistance and cardiovascular complications]. A1 - Janka,H U, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 758 EP - 62 JF - Wiener klinische Wochenschrift JO - Wien. Klin. Wochenschr. VL - 106 IS - 24 N2 - Several epidemiologic and clinical studies over the past years have shown that insulin resistance and hyperinsulinemia are related to dyslipidemia, hypertension, android obesity and non-insulin-dependent diabetes mellitus (NIDDM). The insulin-resistance syndrome is thus closely associated with a cluster of potent cardiovascular risk factors, thereby explaining the 3-4 times higher incidence of cardiovascular disease in NIDDM. Recent observations point to the fact that insulin resistance is genetically determined and can be diagnosed a long time before the clinical manifestation of diabetes mellitus in the prediabetic stage (stage of hyperinsulinemia, hypertension and hyperlipidemia). Hence, it is not surprising that many NIDDM subjects suffer from cardiovascular complications already at the time diabetes is diagnosed. The pathogenetic mechanism of insulin resistance/hyperinsulinemia as cardiovascular risk factor is considered to be a direct atherogenic action of insulin on vessel wall cells and an indirect effect on upper body obesity, blood pressure, lipids and hemostasis. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/7846894/[Insulin_resistance_and_cardiovascular_complications]_ L2 - https://medlineplus.gov/diabetestype2.html DB - PRIME DP - Unbound Medicine ER -