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Is tubal ligation a risk factor for low bone density and increased risk of fracture?

Abstract

OBJECTIVE

Osteoporosis is a major women's health problem, because it is responsible for about 1.3 million fractures in the United States each year. Estrogen deficiency is a major risk factor in the pathogenesis of osteoporosis. Recent evidence has indicated that tubal ligation may cause menstrual dysfunction and estrogen deficiency. This study examined the association between tubal ligation and bone mass in a group of elderly postmenopausal women.

STUDY DESIGN

Subjects were 2215 white women > or = 65 years old participating in the Baltimore center of the Study of Osteoporotic Fractures. Bone mineral density of the proximal and distal radius and the calcaneus was measured by single photon absorptiometry. Multiple regression analysis was performed to determine whether tubal ligation had an independent effect on bone density. The effect of tubal ligation on the risk of hip and osteoporotic fractures was estimated by Cox proportional hazards model.

RESULTS

Women who reported a tubal ligation had lower, although not statistically significant, bone density of the radius and calcaneus. The relative risk of hip (1.05, 95% confidence limit 0.84 to 1.32) and osteoporotic fractures (1.01, 0.80 to 1.29) was not significantly increased in women with tubal ligation.

CONCLUSION

We conclude that elderly women who had a tubal ligation have small changes in bone density that are not of sufficient magnitude to increase their risk of osteoporotic fractures.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore.

    Source

    MeSH

    Absorptiometry, Photon
    Aged
    Bone Density
    Female
    Fractures, Bone
    Hip Fractures
    Humans
    Osteoporosis
    Proportional Hazards Models
    Regression Analysis
    Risk Factors
    Sterilization, Tubal

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    7847513

    Citation

    Fox, K M., and S R. Cummings. "Is Tubal Ligation a Risk Factor for Low Bone Density and Increased Risk of Fracture?" American Journal of Obstetrics and Gynecology, vol. 172, no. 1 Pt 1, 1995, pp. 101-5.
    Fox KM, Cummings SR. Is tubal ligation a risk factor for low bone density and increased risk of fracture? Am J Obstet Gynecol. 1995;172(1 Pt 1):101-5.
    Fox, K. M., & Cummings, S. R. (1995). Is tubal ligation a risk factor for low bone density and increased risk of fracture? American Journal of Obstetrics and Gynecology, 172(1 Pt 1), pp. 101-5.
    Fox KM, Cummings SR. Is Tubal Ligation a Risk Factor for Low Bone Density and Increased Risk of Fracture. Am J Obstet Gynecol. 1995;172(1 Pt 1):101-5. PubMed PMID: 7847513.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Is tubal ligation a risk factor for low bone density and increased risk of fracture? AU - Fox,K M, AU - Cummings,S R, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez KW - Americas KW - Biology KW - Correlation Studies KW - Developed Countries KW - Family Planning KW - Female Sterilization KW - North America KW - Northern America KW - Osteoporosis--women KW - Physiology KW - Research Methodology KW - Risk Factors KW - Skeletal Effects KW - Statistical Studies KW - Sterilization, Sexual KW - Studies KW - Tubal Ligation KW - Tubal Occlusion KW - United States SP - 101 EP - 5 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 172 IS - 1 Pt 1 N2 - OBJECTIVE: Osteoporosis is a major women's health problem, because it is responsible for about 1.3 million fractures in the United States each year. Estrogen deficiency is a major risk factor in the pathogenesis of osteoporosis. Recent evidence has indicated that tubal ligation may cause menstrual dysfunction and estrogen deficiency. This study examined the association between tubal ligation and bone mass in a group of elderly postmenopausal women. STUDY DESIGN: Subjects were 2215 white women > or = 65 years old participating in the Baltimore center of the Study of Osteoporotic Fractures. Bone mineral density of the proximal and distal radius and the calcaneus was measured by single photon absorptiometry. Multiple regression analysis was performed to determine whether tubal ligation had an independent effect on bone density. The effect of tubal ligation on the risk of hip and osteoporotic fractures was estimated by Cox proportional hazards model. RESULTS: Women who reported a tubal ligation had lower, although not statistically significant, bone density of the radius and calcaneus. The relative risk of hip (1.05, 95% confidence limit 0.84 to 1.32) and osteoporotic fractures (1.01, 0.80 to 1.29) was not significantly increased in women with tubal ligation. CONCLUSION: We conclude that elderly women who had a tubal ligation have small changes in bone density that are not of sufficient magnitude to increase their risk of osteoporotic fractures. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/7847513/Is_tubal_ligation_a_risk_factor_for_low_bone_density_and_increased_risk_of_fracture L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(95)90092-6 DB - PRIME DP - Unbound Medicine ER -