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Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone.
Biochem Mol Biol Int. 1994 Sep; 34(2):309-13.BM

Abstract

Soluble organic matrix was extracted with 0.1 M EDTA from calcium oxalate monohydrate urinary stone (CaOx), purified by SDS-polyacrylamide gel electrophoresis and transferred to polyvinylidene difluoride membranes for the NH2-terminal amino acid sequence analysis. A protein at 30 kDa showed complete homology with calprotectin (20 amino acids in the NH2-terminal), so we termed this a calprotectin-like protein. Calprotectin which was extracted from human granulocytes had inhibitory activity in calcium oxalate monohydrate crystal growth in vitro. This study suggested that, calprotectin-like protein detected in CaOx is thought to be a potent inhibitor of crystal growth and may therefore be important in the etiology of CaOx formation.

Authors+Show Affiliations

Department of Urology, Kinki University School of Medicine, Osaka, Japan.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7849642

Citation

Umekawa, T, and T Kurita. "Calprotectin-like Protein Is Related to Soluble Organic Matrix in Calcium Oxalate Urinary Stone." Biochemistry and Molecular Biology International, vol. 34, no. 2, 1994, pp. 309-13.
Umekawa T, Kurita T. Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone. Biochem Mol Biol Int. 1994;34(2):309-13.
Umekawa, T., & Kurita, T. (1994). Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone. Biochemistry and Molecular Biology International, 34(2), 309-13.
Umekawa T, Kurita T. Calprotectin-like Protein Is Related to Soluble Organic Matrix in Calcium Oxalate Urinary Stone. Biochem Mol Biol Int. 1994;34(2):309-13. PubMed PMID: 7849642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone. AU - Umekawa,T, AU - Kurita,T, PY - 1994/9/1/pubmed PY - 1994/9/1/medline PY - 1994/9/1/entrez SP - 309 EP - 13 JF - Biochemistry and molecular biology international JO - Biochem Mol Biol Int VL - 34 IS - 2 N2 - Soluble organic matrix was extracted with 0.1 M EDTA from calcium oxalate monohydrate urinary stone (CaOx), purified by SDS-polyacrylamide gel electrophoresis and transferred to polyvinylidene difluoride membranes for the NH2-terminal amino acid sequence analysis. A protein at 30 kDa showed complete homology with calprotectin (20 amino acids in the NH2-terminal), so we termed this a calprotectin-like protein. Calprotectin which was extracted from human granulocytes had inhibitory activity in calcium oxalate monohydrate crystal growth in vitro. This study suggested that, calprotectin-like protein detected in CaOx is thought to be a potent inhibitor of crystal growth and may therefore be important in the etiology of CaOx formation. SN - 1039-9712 UR - https://www.unboundmedicine.com/medline/citation/7849642/Calprotectin_like_protein_is_related_to_soluble_organic_matrix_in_calcium_oxalate_urinary_stone_ DB - PRIME DP - Unbound Medicine ER -