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Neuromuscular and cardiovascular effects of neostigmine and methyl-atropine administered at different degrees of rocuronium-induced neuromuscular block.
Eur J Anaesthesiol. 1994 Nov; 11(6):481-7.EJ

Abstract

The neuromuscular and cardiovascular effects of neostigmine, 40 micrograms kg-1, and methyl-atropine, 7 micrograms kg-1, administered at different degrees of rocuronium-induced (600 micrograms kg-1) neuromuscular block were evaluated. In one group of patients spontaneous recovery was awaited (Group A; n = 20). Neostigmine and methyl-atropine were administered 2 minutes after rocuronium (Group B; n = 20) or at 25% twitch recovery (Group C; n = 20). Neuromuscular transmission was monitored mechanomyographically. Data are presented as mean (SD) [95%-CI]. The initial rate of recovery (time until a TOF ratio of 0.2) in group B, i.e. 14.2 (4.5) [12.1-16.3] min, was significantly faster than in group C, i.e. 28.7 (5.3) [26.3-31.1] min. However, the time until clinically sufficient recovery (time until a TOF ratio of 0.7) was similar for groups B, i.e. 29.3 (9.5) [24.9-33.7] min and group C, i.e. 31.8 (5.6) [29.2-34.4] min, both significantly different from that of group A, i.e. 53.2 (14.5) [46.5-59.9] min. The increase in heart rate following neostigmine/methyl-atropine was more pronounced in the group reversed at 2 min after rocuronium (P < 0.01).

Authors+Show Affiliations

Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7851356

Citation

Van den Broek, L, et al. "Neuromuscular and Cardiovascular Effects of Neostigmine and Methyl-atropine Administered at Different Degrees of Rocuronium-induced Neuromuscular Block." European Journal of Anaesthesiology, vol. 11, no. 6, 1994, pp. 481-7.
Van den Broek L, Proost JH, Wierda JM, et al. Neuromuscular and cardiovascular effects of neostigmine and methyl-atropine administered at different degrees of rocuronium-induced neuromuscular block. Eur J Anaesthesiol. 1994;11(6):481-7.
Van den Broek, L., Proost, J. H., Wierda, J. M., Njoo, M. D., & Hennis, P. J. (1994). Neuromuscular and cardiovascular effects of neostigmine and methyl-atropine administered at different degrees of rocuronium-induced neuromuscular block. European Journal of Anaesthesiology, 11(6), 481-7.
Van den Broek L, et al. Neuromuscular and Cardiovascular Effects of Neostigmine and Methyl-atropine Administered at Different Degrees of Rocuronium-induced Neuromuscular Block. Eur J Anaesthesiol. 1994;11(6):481-7. PubMed PMID: 7851356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuromuscular and cardiovascular effects of neostigmine and methyl-atropine administered at different degrees of rocuronium-induced neuromuscular block. AU - Van den Broek,L, AU - Proost,J H, AU - Wierda,J M, AU - Njoo,M D, AU - Hennis,P J, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 481 EP - 7 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 11 IS - 6 N2 - The neuromuscular and cardiovascular effects of neostigmine, 40 micrograms kg-1, and methyl-atropine, 7 micrograms kg-1, administered at different degrees of rocuronium-induced (600 micrograms kg-1) neuromuscular block were evaluated. In one group of patients spontaneous recovery was awaited (Group A; n = 20). Neostigmine and methyl-atropine were administered 2 minutes after rocuronium (Group B; n = 20) or at 25% twitch recovery (Group C; n = 20). Neuromuscular transmission was monitored mechanomyographically. Data are presented as mean (SD) [95%-CI]. The initial rate of recovery (time until a TOF ratio of 0.2) in group B, i.e. 14.2 (4.5) [12.1-16.3] min, was significantly faster than in group C, i.e. 28.7 (5.3) [26.3-31.1] min. However, the time until clinically sufficient recovery (time until a TOF ratio of 0.7) was similar for groups B, i.e. 29.3 (9.5) [24.9-33.7] min and group C, i.e. 31.8 (5.6) [29.2-34.4] min, both significantly different from that of group A, i.e. 53.2 (14.5) [46.5-59.9] min. The increase in heart rate following neostigmine/methyl-atropine was more pronounced in the group reversed at 2 min after rocuronium (P < 0.01). SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/7851356/Neuromuscular_and_cardiovascular_effects_of_neostigmine_and_methyl_atropine_administered_at_different_degrees_of_rocuronium_induced_neuromuscular_block_ DB - PRIME DP - Unbound Medicine ER -