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Craniofacial features in patients with deficient and excessive growth hormone.
J Craniofac Genet Dev Biol. 1994 Jul-Sep; 14(3):144-52.JC

Abstract

We studied the role of growth hormone (GH) in craniofacial growth by analyzing the craniofacial structures in patients with either deficient or excessive GH. The cephalogrammes of 21 patients with isolated or combined GH deficiency and of two patients with GH excess were compared with cephalogrammes of age and sex matched controls, and the patients with deficient GH also with height and sex matched controls. In cephalometric measurements, skeletal anatomy was followed as closely as possible. All patients had a Class I or an end-to-end dental occlusion. Head circumference was normal in all patients. Facial widths were significantly smaller in patients with deficient GH but at the level of + 2 SDs in the two with GH excess when compared to Finnish norms. In patients with deficient GH, facial heights were significantly smaller than in age matched controls, but of the same order with height controls for anterior facial height. Posterior facial height was smaller even in this comparison. In patients with GH excess, facial heights were much larger and at the levels of +3 and +6 SD. Clivus was shorter in patients with deficient GH and longer (+ 1.9 and +3 SD) in the two with GH excess. All angulations of the sphenoidal plane deviated from those of the controls in the group with GH deficiency. The cranial base angle (CL-SPhen) was smaller than in controls while it was normal in patients with GH excess. We are inclined to interpret the craniofacial structure of those with deficient GH as being unique to the condition rather than merely negative allometry.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Pedodontics and Orthodontics, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7852543

Citation

Pirinen, S, et al. "Craniofacial Features in Patients With Deficient and Excessive Growth Hormone." Journal of Craniofacial Genetics and Developmental Biology, vol. 14, no. 3, 1994, pp. 144-52.
Pirinen S, Majurin A, Lenko HL, et al. Craniofacial features in patients with deficient and excessive growth hormone. J Craniofac Genet Dev Biol. 1994;14(3):144-52.
Pirinen, S., Majurin, A., Lenko, H. L., & Koski, K. (1994). Craniofacial features in patients with deficient and excessive growth hormone. Journal of Craniofacial Genetics and Developmental Biology, 14(3), 144-52.
Pirinen S, et al. Craniofacial Features in Patients With Deficient and Excessive Growth Hormone. J Craniofac Genet Dev Biol. 1994 Jul-Sep;14(3):144-52. PubMed PMID: 7852543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Craniofacial features in patients with deficient and excessive growth hormone. AU - Pirinen,S, AU - Majurin,A, AU - Lenko,H L, AU - Koski,K, PY - 1994/7/1/pubmed PY - 1994/7/1/medline PY - 1994/7/1/entrez SP - 144 EP - 52 JF - Journal of craniofacial genetics and developmental biology JO - J Craniofac Genet Dev Biol VL - 14 IS - 3 N2 - We studied the role of growth hormone (GH) in craniofacial growth by analyzing the craniofacial structures in patients with either deficient or excessive GH. The cephalogrammes of 21 patients with isolated or combined GH deficiency and of two patients with GH excess were compared with cephalogrammes of age and sex matched controls, and the patients with deficient GH also with height and sex matched controls. In cephalometric measurements, skeletal anatomy was followed as closely as possible. All patients had a Class I or an end-to-end dental occlusion. Head circumference was normal in all patients. Facial widths were significantly smaller in patients with deficient GH but at the level of + 2 SDs in the two with GH excess when compared to Finnish norms. In patients with deficient GH, facial heights were significantly smaller than in age matched controls, but of the same order with height controls for anterior facial height. Posterior facial height was smaller even in this comparison. In patients with GH excess, facial heights were much larger and at the levels of +3 and +6 SD. Clivus was shorter in patients with deficient GH and longer (+ 1.9 and +3 SD) in the two with GH excess. All angulations of the sphenoidal plane deviated from those of the controls in the group with GH deficiency. The cranial base angle (CL-SPhen) was smaller than in controls while it was normal in patients with GH excess. We are inclined to interpret the craniofacial structure of those with deficient GH as being unique to the condition rather than merely negative allometry.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0270-4145 UR - https://www.unboundmedicine.com/medline/citation/7852543/Craniofacial_features_in_patients_with_deficient_and_excessive_growth_hormone_ DB - PRIME DP - Unbound Medicine ER -