Tags

Type your tag names separated by a space and hit enter

Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects.
J Pharmacol Exp Ther. 1995 Feb; 272(2):791-8.JP

Abstract

The effects of cocaine alone and in combination with the calcium channel blockers nimodipine, verapamil and diltiazem were determined for different groups of squirrel monkeys on cardiovascular function, schedule-controlled behavior and drug self-administration. Cocaine alone (0.3 mg/kg) produced increases in both blood pressure and heart rate. All three calcium channel blockers antagonized the pressor effect, but were ineffective against the tachycardiac effect of cocaine. Nimodipine was the most potent agent in antagonizing the pressor effect of cocaine. Response rates for monkeys responding on a second-order schedule of food presentation were increased by intermediate doses of cocaine (0.1-1.0 mg/kg) and were primarily decreased at a higher dose (3.0 mg/kg). Quarter-life values, an index of response patterning, were only decreased by cocaine. None of the calcium channel blockers altered cocaine's effects on either response rate or response patterning. In the self-administration experiments, the training dose of 56 micrograms/kg cocaine maintained high rates of responding on a simple fixed-ratio schedule. As with schedule-controlled behavior, none of the calcium channel blockers altered cocaine self-administration even when administered before self-administration sessions during 5 consecutive days. These results suggest that the calcium channel blockers may be useful in treating cardiovascular-related complications after cocaine use, but they would not be effective as long-term treatment agents for cocaine abuse.

Authors+Show Affiliations

Preclinical Pharmacology Laboratory, Addiction Research Center, Baltimore, Maryland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7853196

Citation

Schindler, C W., et al. "Calcium Channel Blockers Antagonize some of Cocaine's Cardiovascular Effects, but Fail to Alter Cocaine's Behavioral Effects." The Journal of Pharmacology and Experimental Therapeutics, vol. 272, no. 2, 1995, pp. 791-8.
Schindler CW, Tella SR, Prada J, et al. Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects. J Pharmacol Exp Ther. 1995;272(2):791-8.
Schindler, C. W., Tella, S. R., Prada, J., & Goldberg, S. R. (1995). Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects. The Journal of Pharmacology and Experimental Therapeutics, 272(2), 791-8.
Schindler CW, et al. Calcium Channel Blockers Antagonize some of Cocaine's Cardiovascular Effects, but Fail to Alter Cocaine's Behavioral Effects. J Pharmacol Exp Ther. 1995;272(2):791-8. PubMed PMID: 7853196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects. AU - Schindler,C W, AU - Tella,S R, AU - Prada,J, AU - Goldberg,S R, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 791 EP - 8 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 272 IS - 2 N2 - The effects of cocaine alone and in combination with the calcium channel blockers nimodipine, verapamil and diltiazem were determined for different groups of squirrel monkeys on cardiovascular function, schedule-controlled behavior and drug self-administration. Cocaine alone (0.3 mg/kg) produced increases in both blood pressure and heart rate. All three calcium channel blockers antagonized the pressor effect, but were ineffective against the tachycardiac effect of cocaine. Nimodipine was the most potent agent in antagonizing the pressor effect of cocaine. Response rates for monkeys responding on a second-order schedule of food presentation were increased by intermediate doses of cocaine (0.1-1.0 mg/kg) and were primarily decreased at a higher dose (3.0 mg/kg). Quarter-life values, an index of response patterning, were only decreased by cocaine. None of the calcium channel blockers altered cocaine's effects on either response rate or response patterning. In the self-administration experiments, the training dose of 56 micrograms/kg cocaine maintained high rates of responding on a simple fixed-ratio schedule. As with schedule-controlled behavior, none of the calcium channel blockers altered cocaine self-administration even when administered before self-administration sessions during 5 consecutive days. These results suggest that the calcium channel blockers may be useful in treating cardiovascular-related complications after cocaine use, but they would not be effective as long-term treatment agents for cocaine abuse. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/7853196/Calcium_channel_blockers_antagonize_some_of_cocaine's_cardiovascular_effects_but_fail_to_alter_cocaine's_behavioral_effects_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7853196 DB - PRIME DP - Unbound Medicine ER -