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Optic neuritis: a population-based study in Olmsted County, Minnesota.

Abstract

We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regression analysis revealed that age, gender, and calendar year were associated with incidence. The annual age- and sex-adjusted incidence rate was 5.1 per 100,000 person-years from 1985 to 1991. On December 1, 1991, 128 patients with a documented history of ON resided in Olmsted County (prevalence cohort). The age- and sex-adjusted prevalence rate per 100,000 was 115. The average length of follow-up for the incidence cohort was 13.2 years. Life table analysis showed that 39% of the 95 patients with isolated ON in the incidence cohort had progressed to clinically definite multiple sclerosis (MS) by 10 years of follow-up, that 49% had by 20 years, 54% by 30 years, and 60% by 40 years. There was no difference in the risk of developing MS between men and women. The presence of venous sheathing (p = 0.044) and evidence for recurrent ON (p < 0.0001) were associated with an increased likelihood of developing MS. The estimated 25-year survival rate was 88.3% +/- 5.8% for the incidence cohort with isolated ON, compared with 83.9% for the general US population of similar age and sex.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Mayo Clinic, Rochester, MN 55905.

    , , ,

    Source

    Neurology 45:2 1995 Feb pg 244-50

    MeSH

    Adolescent
    Adult
    Age Factors
    Age of Onset
    Aged
    Databases, Factual
    Demography
    Female
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Minnesota
    Optic Neuritis
    Prevalence
    Sex Factors
    Survival Rate
    Time Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    7854520

    Citation

    Rodriguez, M, et al. "Optic Neuritis: a Population-based Study in Olmsted County, Minnesota." Neurology, vol. 45, no. 2, 1995, pp. 244-50.
    Rodriguez M, Siva A, Cross SA, et al. Optic neuritis: a population-based study in Olmsted County, Minnesota. Neurology. 1995;45(2):244-50.
    Rodriguez, M., Siva, A., Cross, S. A., O'Brien, P. C., & Kurland, L. T. (1995). Optic neuritis: a population-based study in Olmsted County, Minnesota. Neurology, 45(2), pp. 244-50.
    Rodriguez M, et al. Optic Neuritis: a Population-based Study in Olmsted County, Minnesota. Neurology. 1995;45(2):244-50. PubMed PMID: 7854520.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Optic neuritis: a population-based study in Olmsted County, Minnesota. AU - Rodriguez,M, AU - Siva,A, AU - Cross,S A, AU - O'Brien,P C, AU - Kurland,L T, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 244 EP - 50 JF - Neurology JO - Neurology VL - 45 IS - 2 N2 - We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regression analysis revealed that age, gender, and calendar year were associated with incidence. The annual age- and sex-adjusted incidence rate was 5.1 per 100,000 person-years from 1985 to 1991. On December 1, 1991, 128 patients with a documented history of ON resided in Olmsted County (prevalence cohort). The age- and sex-adjusted prevalence rate per 100,000 was 115. The average length of follow-up for the incidence cohort was 13.2 years. Life table analysis showed that 39% of the 95 patients with isolated ON in the incidence cohort had progressed to clinically definite multiple sclerosis (MS) by 10 years of follow-up, that 49% had by 20 years, 54% by 30 years, and 60% by 40 years. There was no difference in the risk of developing MS between men and women. The presence of venous sheathing (p = 0.044) and evidence for recurrent ON (p < 0.0001) were associated with an increased likelihood of developing MS. The estimated 25-year survival rate was 88.3% +/- 5.8% for the incidence cohort with isolated ON, compared with 83.9% for the general US population of similar age and sex. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/7854520/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=7854520.ui DB - PRIME DP - Unbound Medicine ER -