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Neurobehavioral and neurophysiological observations in six year old children with low lead levels in East and West Germany.
Neurotoxicology. 1994 Fall; 15(3):705-13.N

Abstract

Within a larger comparative environmental health screening program in East and West Germany neurobehavioral and neurophysiological measures were taken in 367 six year old children in Leipzig (N = 179), Gardelegen (N = 68), and Duisburg (N = 120). Lead concentrations from venous blood samples (PbB) and from deciduous teeth (PbT) were measured as markers of environmental lead exposure by electrothermal AAS. Dependent variables included four subtests from NES1 (tapping, reaction time, pattern comparison, and Benton visual retention), as well as VEP-latencies (N2, P100, N3) evoked by checkerboard patterns of different size and contrast. The overall median blood lead-concentration was 5 micrograms/dl (range: 1.3-19.0 micrograms/dl), and the corresponding tooth lead-concentration was 2 micrograms/g (0.2-14 micrograms/g). The 95-percentile of the overall frequency distribution for PbB was below 10 micrograms/dl. Associations between markers of lead-exposure and neurobehavioral or neurophysiological outcome were assessed by means of multiple linear or logistic regression analyses. After adjusting for relevant confounders/covariates significant (p < 0.05) Pb-related deficit was found for tapping and pattern recognition with respect to PbB but not PbT. No such associations could be established for VEP-latencies. These results are compatible with the hypothesis that subtle neurobehavioral dysfunction in children may be associated with very low PbB.

Authors+Show Affiliations

Medical Institute of Environmental Hygiene, University of Düsseldorf, FRG.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7854610

Citation

Winneke, G, et al. "Neurobehavioral and Neurophysiological Observations in Six Year Old Children With Low Lead Levels in East and West Germany." Neurotoxicology, vol. 15, no. 3, 1994, pp. 705-13.
Winneke G, Altmann L, Krämer U, et al. Neurobehavioral and neurophysiological observations in six year old children with low lead levels in East and West Germany. Neurotoxicology. 1994;15(3):705-13.
Winneke, G., Altmann, L., Krämer, U., Turfeld, M., Behler, R., Gutsmuths, F. J., & Mangold, M. (1994). Neurobehavioral and neurophysiological observations in six year old children with low lead levels in East and West Germany. Neurotoxicology, 15(3), 705-13.
Winneke G, et al. Neurobehavioral and Neurophysiological Observations in Six Year Old Children With Low Lead Levels in East and West Germany. Neurotoxicology. 1994;15(3):705-13. PubMed PMID: 7854610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurobehavioral and neurophysiological observations in six year old children with low lead levels in East and West Germany. AU - Winneke,G, AU - Altmann,L, AU - Krämer,U, AU - Turfeld,M, AU - Behler,R, AU - Gutsmuths,F J, AU - Mangold,M, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 705 EP - 13 JF - Neurotoxicology JO - Neurotoxicology VL - 15 IS - 3 N2 - Within a larger comparative environmental health screening program in East and West Germany neurobehavioral and neurophysiological measures were taken in 367 six year old children in Leipzig (N = 179), Gardelegen (N = 68), and Duisburg (N = 120). Lead concentrations from venous blood samples (PbB) and from deciduous teeth (PbT) were measured as markers of environmental lead exposure by electrothermal AAS. Dependent variables included four subtests from NES1 (tapping, reaction time, pattern comparison, and Benton visual retention), as well as VEP-latencies (N2, P100, N3) evoked by checkerboard patterns of different size and contrast. The overall median blood lead-concentration was 5 micrograms/dl (range: 1.3-19.0 micrograms/dl), and the corresponding tooth lead-concentration was 2 micrograms/g (0.2-14 micrograms/g). The 95-percentile of the overall frequency distribution for PbB was below 10 micrograms/dl. Associations between markers of lead-exposure and neurobehavioral or neurophysiological outcome were assessed by means of multiple linear or logistic regression analyses. After adjusting for relevant confounders/covariates significant (p < 0.05) Pb-related deficit was found for tapping and pattern recognition with respect to PbB but not PbT. No such associations could be established for VEP-latencies. These results are compatible with the hypothesis that subtle neurobehavioral dysfunction in children may be associated with very low PbB. SN - 0161-813X UR - https://www.unboundmedicine.com/medline/citation/7854610/Neurobehavioral_and_neurophysiological_observations_in_six_year_old_children_with_low_lead_levels_in_East_and_West_Germany_ DB - PRIME DP - Unbound Medicine ER -