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Effects of long-term administration of an oral contraceptive containing ethinylestradiol and cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome.

Abstract

BACKGROUND

The effects of an oral contraceptive pill containing cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome (PCOS) was studied.

MATERIALS AND METHODS

Seventy-two women with PCOS were treated for 36 consecutive cycles with an oral contraceptive containing 0.035 mg of ethinylestradiol and 2 mg of cyproterone acetate. Hormonal, lipid and glucose profiles were studied before and after 12 and 36 cycles of treatment. Lipid, lipo-and apolipoprotein values were compared to a healthy control group. Statistical analysis was by one way analysis of variance and Bonferroni's t tests.

RESULTS

The treatment suppressed gonadotropin and androgen values and increased the levels of sex hormone binding globulin. After 12 and 36 cycles a significant increase in triglycerides, high density lipoprotein (HDL) cholesterol system, and apoprotein B levels was seen. Low density lipoprotein (LDL) cholesterol and LDL cholesterol/HDL cholesterol ratio were reduced. Insulin and glucose plasma concentrations did not change. During treatment triglycerides, total cholesterol and apoprotein B values were higher than in the control group. There were no differences in plasma levels of LDL-C and HDL-C in PCOS and in the control group.

CONCLUSION

Lipid and lipoprotein changes observed after treatment could be due to the estrogen dominance of the treatment. The plasma concentration of triglycerides and total cholesterol during treatment does not change appreciably and the LDL-C/HDL-C ratio improved.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Gynecological Endocrinology, University of Brescia, Italy.

    Source

    MeSH

    Adult
    Apoproteins
    Cholesterol
    Contraceptives, Oral, Hormonal
    Cyproterone Acetate
    Dose-Response Relationship, Drug
    Ethinyl Estradiol
    Female
    Humans
    Hyperandrogenism
    Lipid Metabolism
    Lipoproteins
    Polycystic Ovary Syndrome
    Pregnancy
    Testosterone
    Triglycerides

    Pub Type(s)

    Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    7856434

    Citation

    Falsetti, L, and E Pasinetti. "Effects of Long-term Administration of an Oral Contraceptive Containing Ethinylestradiol and Cyproterone Acetate On Lipid Metabolism in Women With Polycystic Ovary Syndrome." Acta Obstetricia Et Gynecologica Scandinavica, vol. 74, no. 1, 1995, pp. 56-60.
    Falsetti L, Pasinetti E. Effects of long-term administration of an oral contraceptive containing ethinylestradiol and cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand. 1995;74(1):56-60.
    Falsetti, L., & Pasinetti, E. (1995). Effects of long-term administration of an oral contraceptive containing ethinylestradiol and cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome. Acta Obstetricia Et Gynecologica Scandinavica, 74(1), pp. 56-60.
    Falsetti L, Pasinetti E. Effects of Long-term Administration of an Oral Contraceptive Containing Ethinylestradiol and Cyproterone Acetate On Lipid Metabolism in Women With Polycystic Ovary Syndrome. Acta Obstet Gynecol Scand. 1995;74(1):56-60. PubMed PMID: 7856434.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of long-term administration of an oral contraceptive containing ethinylestradiol and cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome. AU - Falsetti,L, AU - Pasinetti,E, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez KW - Acne KW - Biology KW - Case Control Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Methods KW - Cyproterone Acetate KW - Dermatitis KW - Developed Countries KW - Diseases KW - Endocrine System KW - Ethinyl Estradiol KW - Europe KW - Family Planning KW - Hormone Antagonists KW - Hormones KW - Italy KW - Lipid Metabolic Effects KW - Lipids KW - Mediterranean Countries KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Ovarian Cysts KW - Physiology KW - Prospective Studies KW - Research Report KW - Southern Europe KW - Studies SP - 56 EP - 60 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 74 IS - 1 N2 - BACKGROUND: The effects of an oral contraceptive pill containing cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome (PCOS) was studied. MATERIALS AND METHODS: Seventy-two women with PCOS were treated for 36 consecutive cycles with an oral contraceptive containing 0.035 mg of ethinylestradiol and 2 mg of cyproterone acetate. Hormonal, lipid and glucose profiles were studied before and after 12 and 36 cycles of treatment. Lipid, lipo-and apolipoprotein values were compared to a healthy control group. Statistical analysis was by one way analysis of variance and Bonferroni's t tests. RESULTS: The treatment suppressed gonadotropin and androgen values and increased the levels of sex hormone binding globulin. After 12 and 36 cycles a significant increase in triglycerides, high density lipoprotein (HDL) cholesterol system, and apoprotein B levels was seen. Low density lipoprotein (LDL) cholesterol and LDL cholesterol/HDL cholesterol ratio were reduced. Insulin and glucose plasma concentrations did not change. During treatment triglycerides, total cholesterol and apoprotein B values were higher than in the control group. There were no differences in plasma levels of LDL-C and HDL-C in PCOS and in the control group. CONCLUSION: Lipid and lipoprotein changes observed after treatment could be due to the estrogen dominance of the treatment. The plasma concentration of triglycerides and total cholesterol during treatment does not change appreciably and the LDL-C/HDL-C ratio improved. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/7856434/Effects_of_long_term_administration_of_an_oral_contraceptive_containing_ethinylestradiol_and_cyproterone_acetate_on_lipid_metabolism_in_women_with_polycystic_ovary_syndrome_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6349&date=1995&volume=74&issue=1&spage=56 DB - PRIME DP - Unbound Medicine ER -