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Accuracy and reliability of frozen section diagnosis in a series of 672 nonpalpable breast lesions.
Am J Clin Pathol. 1995 Feb; 103(2):199-205.AJ

Abstract

Frozen section (FS) diagnosis was routinely performed in a large series of nonpalpable breast lesions from 1977 through 1991. The original FS diagnoses of 672 patients were classified in four categories (1 = benign lesion, 2 = in situ carcinoma, 3 = invasive carcinoma, 4 = deferred diagnosis) and compared with the diagnoses obtained at review of the permanent paraffin sections to estimate the accuracy of FS. A review of the mammographic pattern of the lesion was also performed. Frozen section diagnostic conclusion was deferred to permanent paraffin sections in only 22 cases (3.3%). Benign or malignant (grouping in situ and invasive carcinomas) FS diagnoses were accurate in 623 of 650 cases (95.8%). Overall, the prevalence of malignant lesions was 44.8% with a benign/malignant ratio of 1.2. The diagnosis was modified on the basis of permanent sections in 27 cases (4.2%) with three false positives and 24 false negatives. Sensitivity and specificity of FS diagnoses were 91.7 and 99.2%, respectively. When the comparison between FS and histologic diagnoses was analyzed according to the mammographic pattern, sensitivity among patients with microcalcifications as the only alteration was lower (88.8%) than among patients with opacities (94.9%). On the basis of these results, FS is to be considered a feasible and reliable diagnostic procedure in nonpalpable breast lesions, particularly in cases excised because of a mammographic opacity that is identifiable on gross examination of the surgical specimen.

Authors+Show Affiliations

Istituto di Anatomia e Istologia Patologica, Università di Firenze, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7856563

Citation

Bianchi, S, et al. "Accuracy and Reliability of Frozen Section Diagnosis in a Series of 672 Nonpalpable Breast Lesions." American Journal of Clinical Pathology, vol. 103, no. 2, 1995, pp. 199-205.
Bianchi S, Palli D, Ciatto S, et al. Accuracy and reliability of frozen section diagnosis in a series of 672 nonpalpable breast lesions. Am J Clin Pathol. 1995;103(2):199-205.
Bianchi, S., Palli, D., Ciatto, S., Galli, M., Giorgi, D., Vezzosi, V., Del Turco, M. R., Cataliotti, L., Cardona, G., & Zampi, G. (1995). Accuracy and reliability of frozen section diagnosis in a series of 672 nonpalpable breast lesions. American Journal of Clinical Pathology, 103(2), 199-205.
Bianchi S, et al. Accuracy and Reliability of Frozen Section Diagnosis in a Series of 672 Nonpalpable Breast Lesions. Am J Clin Pathol. 1995;103(2):199-205. PubMed PMID: 7856563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accuracy and reliability of frozen section diagnosis in a series of 672 nonpalpable breast lesions. AU - Bianchi,S, AU - Palli,D, AU - Ciatto,S, AU - Galli,M, AU - Giorgi,D, AU - Vezzosi,V, AU - Del Turco,M R, AU - Cataliotti,L, AU - Cardona,G, AU - Zampi,G, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 199 EP - 205 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 103 IS - 2 N2 - Frozen section (FS) diagnosis was routinely performed in a large series of nonpalpable breast lesions from 1977 through 1991. The original FS diagnoses of 672 patients were classified in four categories (1 = benign lesion, 2 = in situ carcinoma, 3 = invasive carcinoma, 4 = deferred diagnosis) and compared with the diagnoses obtained at review of the permanent paraffin sections to estimate the accuracy of FS. A review of the mammographic pattern of the lesion was also performed. Frozen section diagnostic conclusion was deferred to permanent paraffin sections in only 22 cases (3.3%). Benign or malignant (grouping in situ and invasive carcinomas) FS diagnoses were accurate in 623 of 650 cases (95.8%). Overall, the prevalence of malignant lesions was 44.8% with a benign/malignant ratio of 1.2. The diagnosis was modified on the basis of permanent sections in 27 cases (4.2%) with three false positives and 24 false negatives. Sensitivity and specificity of FS diagnoses were 91.7 and 99.2%, respectively. When the comparison between FS and histologic diagnoses was analyzed according to the mammographic pattern, sensitivity among patients with microcalcifications as the only alteration was lower (88.8%) than among patients with opacities (94.9%). On the basis of these results, FS is to be considered a feasible and reliable diagnostic procedure in nonpalpable breast lesions, particularly in cases excised because of a mammographic opacity that is identifiable on gross examination of the surgical specimen. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/7856563/Accuracy_and_reliability_of_frozen_section_diagnosis_in_a_series_of_672_nonpalpable_breast_lesions_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1093/ajcp/103.2.199 DB - PRIME DP - Unbound Medicine ER -