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[Antiphospholipid and anti beta 2-glycoprotein I antibodies].
Ann Biol Clin (Paris). 1994; 52(5):381-5.AB

Abstract

Recent studies have shown that beta 2glycoprotein I (beta 2GPI), a plasma inhibitor of coagulation with affinity for anionic phospholipids, is frequently required for the formation of the epitopes recognized by some anti-phospholipid antibodies. Six murine monoclonal antibodies directed against human beta 2GPI were compared with anti-beta 2GPI antibodies associated with systemic lupus erythematosus and primary anti-phospholipid syndrome. The beta 2GPI-dependent binding properties to neutral and anionic phospholipids were studied, as well as the target epitopes on the beta 2GPI molecule and the effect of various beta 2GPI treatments to get rid of contaminating phospholipids or to block the beta 2GPI-phospholipid interaction. The results are in favour of a direct binding of patient's antibodies to beta 2GPI, in the absence of phospholipids. Anti-beta 2GPI monoclonal antibodies, two of which inhibited beta 2GPI recognition by the antibodies from patients, possessed lupus-like anticoagulant properties, thereby constituting an interesting model for a subset (beta 2GPI-dependent) of anti-phospholipid antibodies.

Authors+Show Affiliations

Arvieux J
Laboratoire d'immunologie, Centre de transfusion sanguine de Grenoble, La Tronche, France.
Roussel B
No affiliation info available
Colomb MG
No affiliation info available

MeSH

Antibodies, AntiphospholipidAntibodies, MonoclonalAntiphospholipid SyndromeGlycoproteinsHumansLupus Erythematosus, Systemicbeta 2-Glycoprotein I

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

7856939

Citation

Arvieux, J, et al. "[Antiphospholipid and Anti Beta 2-glycoprotein I Antibodies]." Annales De Biologie Clinique, vol. 52, no. 5, 1994, pp. 381-5.
Arvieux J, Roussel B, Colomb MG. [Antiphospholipid and anti beta 2-glycoprotein I antibodies]. Ann Biol Clin (Paris). 1994;52(5):381-5.
Arvieux, J., Roussel, B., & Colomb, M. G. (1994). [Antiphospholipid and anti beta 2-glycoprotein I antibodies]. Annales De Biologie Clinique, 52(5), 381-5.
Arvieux J, Roussel B, Colomb MG. [Antiphospholipid and Anti Beta 2-glycoprotein I Antibodies]. Ann Biol Clin (Paris). 1994;52(5):381-5. PubMed PMID: 7856939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antiphospholipid and anti beta 2-glycoprotein I antibodies]. AU - Arvieux,J, AU - Roussel,B, AU - Colomb,M G, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 381 EP - 5 JF - Annales de biologie clinique JO - Ann Biol Clin (Paris) VL - 52 IS - 5 N2 - Recent studies have shown that beta 2glycoprotein I (beta 2GPI), a plasma inhibitor of coagulation with affinity for anionic phospholipids, is frequently required for the formation of the epitopes recognized by some anti-phospholipid antibodies. Six murine monoclonal antibodies directed against human beta 2GPI were compared with anti-beta 2GPI antibodies associated with systemic lupus erythematosus and primary anti-phospholipid syndrome. The beta 2GPI-dependent binding properties to neutral and anionic phospholipids were studied, as well as the target epitopes on the beta 2GPI molecule and the effect of various beta 2GPI treatments to get rid of contaminating phospholipids or to block the beta 2GPI-phospholipid interaction. The results are in favour of a direct binding of patient's antibodies to beta 2GPI, in the absence of phospholipids. Anti-beta 2GPI monoclonal antibodies, two of which inhibited beta 2GPI recognition by the antibodies from patients, possessed lupus-like anticoagulant properties, thereby constituting an interesting model for a subset (beta 2GPI-dependent) of anti-phospholipid antibodies. SN - 0003-3898 UR - https://www.unboundmedicine.com/medline/citation/7856939/[Antiphospholipid_and_anti_beta_2_glycoprotein_I_antibodies]_ DB - PRIME DP - Unbound Medicine ER -
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