[Isolation and analysis of encephalitogenic fractions of spinal cord proteins].Vopr Med Khim. 1978 Jan-Feb; 24(1):57-62.VM
Main encephalitogenic protein was isolated from bovine medulla spinalis and separated into homogenous polypeptide fractions by gel filtration; some of these fractions had the high encephalitogenic activity. The main protein and its fractions, possessing the encephalitogenic activity, caused a development of cross-reacting antibodies and a sensitization to intracutaneous administration of encephalitogenic preparations in animals. Non-encephalitogenic main protein sensitized animals only to this protein and did not induce the formation of distinct amount of antibodies. The amino acid composition of the encephalitogenic polypeptide is exhibited.