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Late effects of bone marrow transplantation on pulmonary function in children.
Bone Marrow Transplant. 1994 Oct; 14(4):613-21.BM

Abstract

This study was undertaken to evaluate in a primarily pediatric population whether the late effects of bone marrow transplantation (BMT) on pulmonary function in patients having undergone the procedure for treatment of acute leukemia or lymphoma are worse than that of patients having undergone transplant for treatment of aplastic anemia. Forty-six patients were studied. We did not demonstrate statistically significant differences in group mean forced expiratory flow in one second/forced vital capacity (FEV1/FVC) and percentage predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% of the forced vital capacity (FEF25-75) and total lung capacity (TLC) values between the two groups of patients before BMT and to 7 years post-transplant. Individual patients with pulmonary function abnormalities were identified. Furthermore, there were no significant differences between the two study groups or within the group of patients with aplastic anemia from pre-transplant to 9-12 months and from pre-transplant to 18-24 months after BMT. However, within the group of patients treated for acute leukemia or lymphoma, there was a significant decline in the group mean percentage predicted FVC (p = 0.0001), FEV1 (p = 0.0006) and FEF25-75 (p = 0.0063) from pre-transplant to 9-12 months and in the FVC (p = 0.004) and FEV1 (p = 0.0006) from pre-transplant to 18-24 months after BMT. The greater decline in the FVC relative to the FEV1 suggests the development of a restrictive process in this group of patients.

Authors+Show Affiliations

Department of Pediatrics, North Shore University Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7858537

Citation

Kaplan, E B., et al. "Late Effects of Bone Marrow Transplantation On Pulmonary Function in Children." Bone Marrow Transplantation, vol. 14, no. 4, 1994, pp. 613-21.
Kaplan EB, Wodell RA, Wilmott RW, et al. Late effects of bone marrow transplantation on pulmonary function in children. Bone Marrow Transplant. 1994;14(4):613-21.
Kaplan, E. B., Wodell, R. A., Wilmott, R. W., Leifer, B., Lesser, M. L., & August, C. S. (1994). Late effects of bone marrow transplantation on pulmonary function in children. Bone Marrow Transplantation, 14(4), 613-21.
Kaplan EB, et al. Late Effects of Bone Marrow Transplantation On Pulmonary Function in Children. Bone Marrow Transplant. 1994;14(4):613-21. PubMed PMID: 7858537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Late effects of bone marrow transplantation on pulmonary function in children. AU - Kaplan,E B, AU - Wodell,R A, AU - Wilmott,R W, AU - Leifer,B, AU - Lesser,M L, AU - August,C S, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 613 EP - 21 JF - Bone marrow transplantation JO - Bone Marrow Transplant. VL - 14 IS - 4 N2 - This study was undertaken to evaluate in a primarily pediatric population whether the late effects of bone marrow transplantation (BMT) on pulmonary function in patients having undergone the procedure for treatment of acute leukemia or lymphoma are worse than that of patients having undergone transplant for treatment of aplastic anemia. Forty-six patients were studied. We did not demonstrate statistically significant differences in group mean forced expiratory flow in one second/forced vital capacity (FEV1/FVC) and percentage predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% of the forced vital capacity (FEF25-75) and total lung capacity (TLC) values between the two groups of patients before BMT and to 7 years post-transplant. Individual patients with pulmonary function abnormalities were identified. Furthermore, there were no significant differences between the two study groups or within the group of patients with aplastic anemia from pre-transplant to 9-12 months and from pre-transplant to 18-24 months after BMT. However, within the group of patients treated for acute leukemia or lymphoma, there was a significant decline in the group mean percentage predicted FVC (p = 0.0001), FEV1 (p = 0.0006) and FEF25-75 (p = 0.0063) from pre-transplant to 9-12 months and in the FVC (p = 0.004) and FEV1 (p = 0.0006) from pre-transplant to 18-24 months after BMT. The greater decline in the FVC relative to the FEV1 suggests the development of a restrictive process in this group of patients. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/7858537/Late_effects_of_bone_marrow_transplantation_on_pulmonary_function_in_children_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -