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Proinsulin as a marker for the development of NIDDM in Japanese-American men.
Diabetes. 1995 Feb; 44(2):173-9.D

Abstract

Disproportionate hyperproinsulinemia is one manifestation of the B-cell dysfunction observed in non-insulin-dependent diabetes mellitus (NIDDM), but it is unclear when this abnormality develops and whether it predicts the development of NIDDM. At baseline, measurements of proinsulin (PI) and immunoreactive insulin (IRI) levels were made in 87 second-generation Japanese-American men, a population at high risk for the subsequent development of NIDDM, and, by using World Health Organization criteria, subjects were categorized as having normal glucose tolerance (NGT; n = 49) or impaired glucose tolerance (IGT; n = 38). After a 5-year follow-up period, they were recategorized as NGT, IGT, or NIDDM using the same criteria. After 5 years, 16 subjects had developed NIDDM, while 71 had NGT or IGT. Individuals who developed NIDDM were more obese at baseline, measured as intra-abdominal fat (IAF) area on computed tomography (P = 0.046) but did not differ in age from those who continued to have NGT or IGT. At baseline, subjects who subsequently developed NIDDM had higher fasting glucose (P = 0.0042), 2-h glucose (P = 0.0002), fasting C-peptide (P = 0.0011), and fasting PI levels (P = 0.0033) and disproportionate hyperproinsulinemia (P = 0.056) than those who continued to have NGT or IGT after 5 years of follow-up. NIDDM incidence was positively correlated with the absolute fasting PI level (relative odds = 2.35; P = 0.0025), even after adjustment for fasting IRI, IAF, and body mass index (relative odds = 2.17; P = 0.013).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, University of Washington, Seattle.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7859937

Citation

Kahn, S E., et al. "Proinsulin as a Marker for the Development of NIDDM in Japanese-American Men." Diabetes, vol. 44, no. 2, 1995, pp. 173-9.
Kahn SE, Leonetti DL, Prigeon RL, et al. Proinsulin as a marker for the development of NIDDM in Japanese-American men. Diabetes. 1995;44(2):173-9.
Kahn, S. E., Leonetti, D. L., Prigeon, R. L., Boyko, E. J., Bergstrom, R. W., & Fujimoto, W. Y. (1995). Proinsulin as a marker for the development of NIDDM in Japanese-American men. Diabetes, 44(2), 173-9.
Kahn SE, et al. Proinsulin as a Marker for the Development of NIDDM in Japanese-American Men. Diabetes. 1995;44(2):173-9. PubMed PMID: 7859937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proinsulin as a marker for the development of NIDDM in Japanese-American men. AU - Kahn,S E, AU - Leonetti,D L, AU - Prigeon,R L, AU - Boyko,E J, AU - Bergstrom,R W, AU - Fujimoto,W Y, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 173 EP - 9 JF - Diabetes JO - Diabetes VL - 44 IS - 2 N2 - Disproportionate hyperproinsulinemia is one manifestation of the B-cell dysfunction observed in non-insulin-dependent diabetes mellitus (NIDDM), but it is unclear when this abnormality develops and whether it predicts the development of NIDDM. At baseline, measurements of proinsulin (PI) and immunoreactive insulin (IRI) levels were made in 87 second-generation Japanese-American men, a population at high risk for the subsequent development of NIDDM, and, by using World Health Organization criteria, subjects were categorized as having normal glucose tolerance (NGT; n = 49) or impaired glucose tolerance (IGT; n = 38). After a 5-year follow-up period, they were recategorized as NGT, IGT, or NIDDM using the same criteria. After 5 years, 16 subjects had developed NIDDM, while 71 had NGT or IGT. Individuals who developed NIDDM were more obese at baseline, measured as intra-abdominal fat (IAF) area on computed tomography (P = 0.046) but did not differ in age from those who continued to have NGT or IGT. At baseline, subjects who subsequently developed NIDDM had higher fasting glucose (P = 0.0042), 2-h glucose (P = 0.0002), fasting C-peptide (P = 0.0011), and fasting PI levels (P = 0.0033) and disproportionate hyperproinsulinemia (P = 0.056) than those who continued to have NGT or IGT after 5 years of follow-up. NIDDM incidence was positively correlated with the absolute fasting PI level (relative odds = 2.35; P = 0.0025), even after adjustment for fasting IRI, IAF, and body mass index (relative odds = 2.17; P = 0.013).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/7859937/Proinsulin_as_a_marker_for_the_development_of_NIDDM_in_Japanese_American_men_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&pmid=7859937 DB - PRIME DP - Unbound Medicine ER -