Tags

Type your tag names separated by a space and hit enter

Effects of long-term therapy with enalapril on severity of functional mitral regurgitation in dogs with moderate heart failure.
J Am Coll Cardiol. 1995 Mar 01; 25(3):768-72.JACC

Abstract

OBJECTIVES

This study examined the effects of early long-term monotherapy with enalapril on the severity of functional mitral regurgitation in dogs with moderate heart failure.

BACKGROUND

Functional mitral regurgitation often develops in patients with heart failure and, depending on its severity, can have a marked adverse impact on the stroke output of the failing left ventricle and contribute to progressive deterioration of the heart failure state.

METHODS

Left ventricular dysfunction (ejection fraction 30% to 40%) was produced in 14 dogs by multiple sequential intracoronary microembolizations. Dogs were randomized to 3 months of therapy with enalapril (10 mg twice daily, n = 7) or no therapy at all (control, n = 7). The severity of functional mitral regurgitation was quantified by Doppler color flow mapping in seven control and six enalapril-treated dogs. Mitral annular diameter was assessed by echocardiography and left ventricular volumes and shape by ventriculography. Measurements were made before initiation and after completion of therapy.

RESULTS

In control dogs, the severity of mitral regurgitation increased during the follow-up period ([mean +/- SEM] 14 +/- 4 vs. 23 +/- 4%, p < 0.001) and was associated with increased left ventricular end-systolic and end-diastolic volumes. In contrast, the severity of regurgitation was not significantly changed in dogs treated with enalapril (18 +/- 3 vs. 16 +/- 6%, p < 0.59) and was associated with preservation of left ventricular volumes.

CONCLUSIONS

In dogs with moderate heart failure, early long-term therapy with enalapril prevents progressive worsening of functional mitral regurgitation. This beneficial effect is most likely achieved by prevention of progressive left ventricular dilation.

Authors+Show Affiliations

Department of Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7860927

Citation

Shimoyama, H, et al. "Effects of Long-term Therapy With Enalapril On Severity of Functional Mitral Regurgitation in Dogs With Moderate Heart Failure." Journal of the American College of Cardiology, vol. 25, no. 3, 1995, pp. 768-72.
Shimoyama H, Sabbah HN, Rosman H, et al. Effects of long-term therapy with enalapril on severity of functional mitral regurgitation in dogs with moderate heart failure. J Am Coll Cardiol. 1995;25(3):768-72.
Shimoyama, H., Sabbah, H. N., Rosman, H., Kono, T., Alam, M., & Goldstein, S. (1995). Effects of long-term therapy with enalapril on severity of functional mitral regurgitation in dogs with moderate heart failure. Journal of the American College of Cardiology, 25(3), 768-72.
Shimoyama H, et al. Effects of Long-term Therapy With Enalapril On Severity of Functional Mitral Regurgitation in Dogs With Moderate Heart Failure. J Am Coll Cardiol. 1995 Mar 1;25(3):768-72. PubMed PMID: 7860927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of long-term therapy with enalapril on severity of functional mitral regurgitation in dogs with moderate heart failure. AU - Shimoyama,H, AU - Sabbah,H N, AU - Rosman,H, AU - Kono,T, AU - Alam,M, AU - Goldstein,S, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 768 EP - 72 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 25 IS - 3 N2 - OBJECTIVES: This study examined the effects of early long-term monotherapy with enalapril on the severity of functional mitral regurgitation in dogs with moderate heart failure. BACKGROUND: Functional mitral regurgitation often develops in patients with heart failure and, depending on its severity, can have a marked adverse impact on the stroke output of the failing left ventricle and contribute to progressive deterioration of the heart failure state. METHODS: Left ventricular dysfunction (ejection fraction 30% to 40%) was produced in 14 dogs by multiple sequential intracoronary microembolizations. Dogs were randomized to 3 months of therapy with enalapril (10 mg twice daily, n = 7) or no therapy at all (control, n = 7). The severity of functional mitral regurgitation was quantified by Doppler color flow mapping in seven control and six enalapril-treated dogs. Mitral annular diameter was assessed by echocardiography and left ventricular volumes and shape by ventriculography. Measurements were made before initiation and after completion of therapy. RESULTS: In control dogs, the severity of mitral regurgitation increased during the follow-up period ([mean +/- SEM] 14 +/- 4 vs. 23 +/- 4%, p < 0.001) and was associated with increased left ventricular end-systolic and end-diastolic volumes. In contrast, the severity of regurgitation was not significantly changed in dogs treated with enalapril (18 +/- 3 vs. 16 +/- 6%, p < 0.59) and was associated with preservation of left ventricular volumes. CONCLUSIONS: In dogs with moderate heart failure, early long-term therapy with enalapril prevents progressive worsening of functional mitral regurgitation. This beneficial effect is most likely achieved by prevention of progressive left ventricular dilation. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/7860927/Effects_of_long_term_therapy_with_enalapril_on_severity_of_functional_mitral_regurgitation_in_dogs_with_moderate_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0735-1097(94)00426-Q DB - PRIME DP - Unbound Medicine ER -